ORs for optic neuropathy in relation to average daily dosage of ethambutol (EMB) prescription
| OR (95% CI) | ||||
|---|---|---|---|---|
| Controls (n=924) % | Optic neuropathy cases (n=231) % | Average daily dose, mg | Model 1 | Model 2 |
| All EMB-treated cases | ||||
| <800 | 439 (47.5) | 115 (49.8) | 1.00 | 1.00 |
| 800–1199 | 290 (31.4) | 88 (38.1) | 1.28 (0.93 to 1.76) | 1.36 (0.98 to 1.89) |
| ≧1200 | 195 (21.1) | 28 (12.1) | 0.68 (0.43 to 1.09) | 0.72 (0.45 to 1.16) |
| With renal diseases | ||||
| <800 | 24 (61.5) | 21 (72.4) | 1.00 | 1.00 |
| 800–1199 | 13 (33.3) | 7 (24.1) | 0.39 (0.11 to 1.36) | 0.40 (0.11 to 1.40) |
| ≧1200 | 2 (5.13) | 1 (3.45) | 0.41 (0.03 to 5.36) | 0.37 (0.03 to 4.91) |
| Without renal diseases | ||||
| <800 | 415 (46.9) | 94 (46.5) | 1.00 | 1.00 |
| 800–1199 | 277 (31.3) | 81 (40.1) | 1.44 (1.02 to 2.03) | 1.46 (1.04 to 2.06)* |
| ≧1200 | 193 (21.8) | 27 (13.4) | 0.79 (0.49 to 1.28) | 0.78 (0.48 to 1.26) |
Model 1 was adjusted for age and sex.
Model 2 was additionally adjusted for hypertension and renal diseases.
Average daily dose was calculated by dividing total number of milligrams prescribed by total number of days supplied during the year before the index date.