Clinical feature, treatment, and outcome of intralesional injection of pingyangmycin of the 13 patients with orbital vascular malformations
| Location | Proptosis | Volume of lesion | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | Sex | Age (year) | Eye | Course of disease (months) | Presenting symptom | Diagnosis | Muscle cone | Quadrant | Orbital apex | Dosage (mg) | Pre (mm) | Post (mm) | Reduction (mm) | Pre (cm3) | Post (cm3) | Reduction (cm3) | Reduction (%) | Interval to post imaging (months) | Interval to final follow-up (months) |
| 1 | F | 38 | os | 0.3 | Slight pain | VM | Outer | N | No | 4.0 | 1.5 | 0.0 | 1.5 | 1.7 | 0.3 | 1.4 | 81.6 | 21.4 | 21.7 |
| 2 | M | 52 | od | 2.0 | Proptosis, swelling | VM | Inner | NI | No | 4.0 | 6.0 | 0.5 | 5.5 | 3.8 | 2.5 | 1.3 | 34.6 | 1.6 | 21.2 |
| 3 | F | 39 | os | 36 | Proptosis, swelling | CH | Inner | C | Yes | 5.0 | 6.0 | 0.5 | 5.5 | 4.5 | 1.4 | 3.1 | 69.0 | 2.1 | 20.0 |
| 4* | F | 16 | os | 84 | Proptosis, swelling | CH | Inner | S | Yes | 6.0 | 5.5 | 2.5 | 3.0 | 8.8 | 6.6 | 2.2 | 24.5 | 4.3 | 23.4 |
| 5 | F | 58 | od | 1.0 | Incidental CT finding | CH | Inner | C | Yes | 4.0 | 2.0 | 0.0 | 2.0 | 4.7 | 0.6 | 4.0 | 86.4 | 15.9 | 16.3 |
| 6 | M | 28 | os | 0.8 | Proptosis, swelling | CH | Inner | C | Yes | 4.0 | 5.0 | 0.0 | 5.0 | 7.7 | 1.4 | 6.3 | 81.5 | 2.1 | 2.6 |
| 7 | M | 36 | os | 0.7 | Proptosis, Valsalva(+) | VM | Inner | N | No | 6.0 | 3.0 | 0.0 | 3.0 | 4.8 | 1.8 | 3.0 | 61.7 | 8.8 | 9.1 |
| 8 | M | 16 | od | 1.0 | Proptosis | VM | Inner | TS | Yes | 4.0 | 5.0 | 0.0 | 5.0 | 6.5 | 1.8 | 4.8 | 72.8 | 2.5 | 2.5 |
| 9 | F | 34 | od | 120 | Proptosis, Valsalva(+) | VM | Inner | TS | Yes | 2.0 | 3.0 | 0.0 | 3.0 | 1.7 | 0.5 | 1.2 | 70.6 | 1.9 | 2.5 |
| 10 | F | 48 | od | 0.5 | Slight pain | VM | Inner | NS | No | 4.0 | 0.0 | 0.0 | 0.0 | 1.6 | 0.2 | 1.4 | 88.3 | 17.2 | 17.5 |
| 11 | F | 42 | od | 10 | Slight fullness | CH | Inner | C | Yes | 4.0 | 0.0 | 0.0 | 0.0 | 2.6 | 0.4 | 2.2 | 84.8 | 18.9 | 18.9 |
| 12 | F | 21 | os | 84 | Proptosis, strabismus | L | Inner and outer | NS | Yes | 4.0 | 4.0 | 0.0 | 4.0 | 4.0 | 0.7 | 3.3 | 82.6 | 13.3 | 13.3 |
| 13 | M | 41 | os | 60 | Proptosis, diplopia | CH | Inner | C | Yes | 4.0 | 3.5 | −1.0 | 4.5 | 5.1 | 1.4 | 3.6 | 71.9 | 3.0 | 4.5 |
*Patient underwent a second injection of pingyangmycin during follow-up when an biopsy was performed to study pathological changes due to pingyangmycin treatment; postoperative proptosis (2.5 mm) and volume of this lesion (6.6 cm3) are given as measured after the first injection.
C, central; CH, cavernous haemangioma; I, inferior; L, lymphangioma; N, nasal; S, superior; T, temporal; VM, venous malformation.