Visual outcomes following intraophthalmic artery melphalan for retinoblastoma: Dose, complications and results
| Patient number | Dose and (number of IAM treatments) | Revised dose according to age21 (months) | Catheterisation complications | Tumour controlled | Choroidal ischaemia/Retinal detachment | Visual function deterioration |
|---|---|---|---|---|---|---|
| 1 | 5 mg (2) | 4 mg (15) | During 1st infusion technical difficulties due to unfavourable anatomy | Yes | Yes | Yes |
| 2 | 5 mg (2) | 4 mg (24) | During 2nd infusion transient oxygen desaturation following heparin | Yes | Yes | Yes |
| 3 | 5 mg (2) | 3 mg (11) | None | Yes | Yes | No |
| 4 | 5 mg (2) | 4 mg (24) | During 2nd infusion transient hypotensive event following heparin+contrast | Yes | No | No |
| 5 | 5 mg (2) | 3 mg (11) | During 1st infusion technical difficulties due to unfavourable anatomy | Yes | Yes | Yes |
| 6 | 5 mg (2) | 4 mg (24) | During 2nd infusion transient hypotensive event following contrast | Yes | No | No |
| 7 | 5 mg (1) | 3 mg (11) | None | Yes | Yes | No |
| 8 | 5mg+7.5mg* (5) | 5 mg (40) | During 4th dose vasospasm of ophthalmic artery due to manipulation | Partial (peripheral relapse) | Yes | Yes |
| 9 | 5mg+7.5mg** (3) | 5 mg (82) | None | Yes | Yes | Yes |
| 10 | 3 mg (2) | 3 mg (9) | None | Yes | No | No |
| 11 | 5 mg (3) | 3 mg (11) | During 3rd dose transient fall in tidal volume, BP and heart rate due to manipulation | Partial (edge relapse) | Yes | No |
| 12 | 5 mg (3) | 5 mg (73) | During 2nd and 3rd doses transient fall in tidal volume, BP due to manipulation | Partial (vitreous seeds) | No | No |
Bold text shows severe complications. IAM, intra-arterial melphalan.