Grade | Clinical scoring of EAU Histopathological scoring of EAU | SD-OCT scoring of EAU | |
---|---|---|---|
0 | No change | No change | No abnormal image |
0.5 | Few (1–2) very small focal lesions Minimal vasculitis/vitritis | Few inflammatory cells in the vitreous and retina No tissue damage | |
1 | Optic disc redness Mild retinal vasculitis <5 small focal retinal lesions | Mild inflammatory cells in the vitreous and retina Perivasculitis | Few high reactive dots in the vitreous and around retinal vessels |
2 | Optic disc swelling Moderate retinal vasculitis Multiple (>5) retinal lesions | Increased inflammatory cells in the vitreous Severe perivasculitis Granulomatous infiltrates Retinal fold Partial photoreceptor loss | High reactive dots in the vitreous and around retinal vessels more than grade 1 High reactive dots in the retinal all layer Few high reactive mass in the outer retina Partial retinal layer disruption |
3 | Severe retinal vasculitis Retinal haemorrhages Extended retinal exudates | Multiple granulomatous infiltrates Destruction of all retina laminar structure Extensive photoreceptor loss | Many high reactive dots in the vitreous, around vessels, and in all retinal layers Multiple high reactive mass in the outer retina Disturbance of the total retinal layer structures Disappearance of ELM and IS/OS line |
4 | Pale optic disc Narrow retinal vessels Extensive retinal atrophy | Disappearance of the outer retinal layers | Disappearance of the outer retinal layers |
EAU, experimental autoimmune uveoretinitis; ELM, external limiting membrane; hIRBP, human interphotoreceptor retinoid-binding protein; IS/OS, inner segment/outer segment; SD-OCT, spectral domain optical coherence tomography.