Responders (%)* | |||
---|---|---|---|
Time point | Bimatoprost /timolol PF | Bimatoprost/timolol | Treatment difference (95% CI)† p Value‡ |
8:00 | 90.6% (252/278) | 89.8% (254/283) | 0.9% (–4.0% to 5.8%) 0.722 |
10:00 | 86.3% (240/278) | 85.5% (242/283) | 0.8% (–4.9% to 6.6%) 0.780 |
16:00 | 87.1% (242/278) | 83.4% (236/283) | 3.7% (–2.2% to 9.5%) 0.222 |
*Responders are defined as patients with a ≥20% reduction from baseline in worse eye IOP at week 12. Worse eye is the eye with the higher mean diurnal IOP at baseline.
†95% CI of treatment differences was constructed using the normal approximation for the binomial distribution.
‡Pearson's χ^{2} test of the equality of proportions between treatment groups.
IOP, intraocular pressure; PF, preservative-free.