Univariate analysis of risk factors for metastasis
| Prognostic factors | N=338 | Metastatic events | Two-year survival rate ± SD | HR | p Value |
|---|---|---|---|---|---|
| Age at uveal melanoma diagnosis | |||||
| <60 years | 177 | 52 | 71.9±4 | 1 | 0.02 |
| ≥60 years | 161 | 66 | 56.8±4.5 | 1.50 (1.05–2.17) | |
| Gender | |||||
| Men | 202 | 64 | 66.5±3.8 | 1 | 0.168 NS |
| Women | 136 | 54 | 61.8± 4.8 | 1. 26 (0.88–1.08) | |
| Ocular tumour diameter | |||||
| ≤15 mm | 134 | 32 | 78.3±4.2 | 1 | 0.0007 |
| >15 mm (md=17) | 187 | 78 | 56.3±4.2 | 2.0 (1.33–3.0) | |
| Ocular tumour thickness | |||||
| ≤10 mm | 159 | 42 | 72.5±4 | 1 | 0.01 |
| >10 mm (md=1) | 178 | 76 | 57.4±4 | 1.6 (1.1–2.3) | |
| Ocular tumour location | |||||
| Anterior to equator | 19 | 7 | 45.0±14 | 1 | 0.411 NS |
| On equator | 234 | 85 | 63.7±3.6 | 1.2 (0.38–18) | |
| Posterior to equator (md=4) | 81 | 24 | 73.0± 6 | 1.6 (0.26–1.44) | |
| Retinal detachment | |||||
| No | 94 | 31 | 66.6±6 | 1 | 0.343 NS |
| Yes (md=16) | 228 | 77 | 65.4±3 | 1.22 (0.80–1.8) | |
| Histological type | |||||
| Spindle | 78 | 22 | 76.0±5.3 | 1 | 0.0009 |
| Epithelioid—mixed (md=91) | 169 | 78 | 54.7±4.4 | 2.2 (1.3–3.5) | |
| Genomic data | |||||
| D3/8nl | 91 | 2 | 100±0 | 1 | <0.0001 |
| D3/8g | 47 | 8 | 85.0±6 | 8.1 (01.7–38.2) | |
| M3/8nl | 41 | 8 | 82.1±6 | 9.3 (01.9–44.2) | |
| M3/8g | 159 | 100 | 37.1±4 | 46.6 (11.4–189.4) | |
Metastasis rate was estimated by the Kaplan–Meier method and the HR was determined by the Cox model (md, missing data).