Demographics and initial ocular characteristics
| BCVA responders (120 eyes) | BCVA non-responders (21 eyes) | Fundus responders (117 eyes) | Fundus non-responders (24 eyes) | |
|---|---|---|---|---|
| Age, mean±SD | 72.6±10.1 | 75.9±5.4* | 72.9±9.9 | 73.6±7.9 |
| Male/female gender, no. eyes (male %) | 80/40 (66.6) | 15/6 (71.4) | 78/39 (66.6) | 17/7 (70.8) |
| BCVA, logMAR (mean±SD) | 0.39±0.44 | 0.52±0.35 | 0.41±0.45 | 0.41±0.33 |
| AMD type | ||||
| Typical AMD | 73 | 10 | 64 | 19 |
| PCV | 34 | 9 | 38 | 5 |
| RAP | 13 | 2 | 15 | 0 |
| CRT, mean±SD (μm) | 404.8±185.7 | 484.2±269.5 | 426.2±209.2 | 361.8±141.0 |
| GLD, mean±SD (μm) | 3432.1±2207.4 | 4007.8±2104.2 | 3429.8±2085.1 | 3947.0±2675.9 |
| Type 1 CNV, no. eyes (%) | 74 (61.7) | 18 (75.0) | 68 (58.1) | 22 (91.7)** |
| Fundus findings, no. eyes (%) | ||||
| Serous PED | 50 (41.7) | 11 (52.4) | 52 (44.4) | 9 (37.5) |
| Fibrovascular PED | 35 (29.2) | 11 (52.4) | 30 (25.7) | 16 (66.6)** |
| Haemorrhagic PED | 11 (9.2) | 6 (28.6) | 14 (20.0) | 3 (4.2) |
| Serous retinal detachment | 71 (59.2) | 13 (61.9) | 70 (59.8) | 14 (54.2) |
| Macular oedema | 30 (33.3) | 6 (28.6) | 33 (28.2) | 3 (12.5)** |
| Retinal haemorrhage | 38 (32.5) | 7 (33.3) | 39 (33.3) | 6 (25.0) |
*p<0.05, **p<0.01.
AMD, age-related macular degeneration; BCVA, best corrected visual acuity; CNV, choroidal neovascularisation; CRT, central retinal thickness; GLD, greatest linear dimension; PCV, polypoidal choroidal vasculopathy; PED, pigment epithelial detachment; RAP, retinal angiomatous proliferation.