Drug comparisons | No. of trials (participants) (ref) | Event rate n/N | I2 | p Value (het) | RR (95% CI) | p Value (effect) | NNT (95% CI) |
---|---|---|---|---|---|---|---|
Ocular discomfort | |||||||
Ofloxacin compared with | |||||||
Aminoglycoside–cephalosporin | 2 (292)17 23 | Oflox 11/147 A/C 47/145 | 0% | 0.97 | 0.22 (0.13 to 0.39) | <0.00001* | 4 (3 to 5) |
Tobramycin–cefazolin compared with | |||||||
Fluoroquinolone | 3 (693)17 20 23 | T/C 82/309 Fluoro 27/384 | 48% | 0.14 | 3.13 (2.13 to 4.60) | <0.00001* | 6 (5 to 8) |
Fluoroquinolone compared with | |||||||
Aminoglycoside–cephalosporin | 3 (693)17 20 23 | Fluoro 27/384 A/C82/309 | 48% | 0.14 | 0.32 (0.22 to 0.47) | <0.00001* | 6 (5 to 8) |
Chemical conjunctivitis | |||||||
Ofloxacin compared with | |||||||
Aminoglycoside–cephalosporin | 3 (410)17 23 26 | Oflox 7/206 A/C37/204 | 0% | 1.00 | 0.20 (0.10 to 0.41) | <0.0001* | 7 (5 to 10) |
Tobramycin–cefazolin compared with | |||||||
Fluoroquinolone | 2 (369)17 23 | T/C 3/151 Fluoro 5/144 | 0% | 0.08 | 0.60 (0.16 to 2.23) | 0.45 | NA |
White precipitate | |||||||
Ciprofloxacin compared with | |||||||
Gentamicin–cefazolin | 2 (71)23 30 | Cipro 4/32 G/C 0/39 | 0% | 0.59 | 6.06 (0.77 to 47.45) | 0.09 | NA |
Aminoglycoside–cephalosporin | 3 (395)20 22 30 | Cipro 32/192 A/C 0/203 | 20% | 0.29 | 24.37 (4.68 to 126.89) | 0.0001* | 6 (4 to 9) |
p<0.05 is considered significant.
*Statistically significant outcome.
A/C, aminoglycoside–cephalosporin; Cipro, ciprofloxacin; Fluoro, fluoroquinolone; G/C, gentamicin–cefazolin; het, heterogeneity; I2, inconsistency index; n/N, number of participants with treatment success in each study arm/total number of participants in each study arm; NA, not applicable; NNT, number needed to treat; Oflox, ofloxacin; Ref, reference; RR, relative risk; T/C, tobramycin–cefazolin.