LBN 0.006% (n=82) | LBN 0.012% (n=85) | LBN 0.024% (n=83) | LBN 0.040% (n=81) | Latanoprost 0.005% (n=82) | |
---|---|---|---|---|---|

Day 7 (Visit 4) | |||||

Mean diurnal CFB | |||||

LS mean | 6.86 | 7.67 | 8.27 | 8.48 | 7.29 |

Difference (95% CI) | −0.43 (−1.33 to 0.47) | 0.39 (−0.51 to 1.28) | 0.98 (0.08 to 1.88) | 1.19 (0.29 to 2.09) | |

p Value* | 0.352 | 0.398 | 0.033 | 0.009 | |

CFB at 08:00 | |||||

LS mean | 7.29 | 8.31 | 8.76 | 8.89 | 8.01 |

Difference (95% CI) | −0.72 (−1.76 to 0.32) | 0.30 (−0.73 to 1.33) | 0.75 (−0.28 to 1.78) | 0.88 (−0.15 to 1.91) | |

p Value | 0.174 | 0.57 | 0.155 | 0.095 | |

CFB at 12:00 | |||||

LS mean | 6.69 | 7.64 | 8.29 | 8.33 | 7.21 |

Difference (95% CI) | −0.53 (−1.51 to 0.46) | 0.43 (−0.55 to 1.40) | 1.07 (0.10 to 2.05) | 1.12 (0.14 to 2.10) | |

p Value | 0.293 | 0.390 | 0.032 | 0.026 | |

CFB at 16:00 | |||||

LS mean | 6.63 | 7.00 | 7.80 | 8.26 | 6.61 |

Difference (95% CI) | 0.02 (−0.96 to 1.01) | 0.39 (−0.59 to 1.36) | 1.19 (0.21 to 2.16) | 1.65 (0.68 to 2.63) | |

p Value | 0.963 | 0.433 | 0.017 | 0.001 | |

Day 14 (Visit 5) | |||||

Mean diurnal CFB | |||||

LS mean | 7.61 | 7.93 | 8.86 | 8.61 | 7.72 |

Difference (95% CI) | −0.11 (−1.04 to 0.81) | 0.22 (−0.70 to 1.13) | 1.14 (0.23 to 2.05) | 0.89 (−0.03 to 1.80) | |

p Value | 0.812 | 0.644 | 0.015 | 0.057 | |

CFB at 08:00 | |||||

LS mean | 8.34 | 8.46 | 9.66 | 9.04 | 8.42 |

Difference (95% CI) | −0.08 (−1.10 to 0.94) | 0.04 (−0.96 to 1.04) | 1.24 (0.24 to 2.24) | 0.62 (−0.38 to 1.62) | |

p Value | 0.877 | 0.941 | 0.016 | 0.225 | |

CFB at 12:00 | |||||

LS mean | 7.50 | 8.38 | 8.70 | 8.56 | 7.52 |

Difference (95% CI) | −0.02 (−1.08 to 1.05) | 0.86 (−0.19 to 1.91) | 1.18 (0.13 to 2.23) | 1.04 (−0.01 to 2.09) | |

p Value | 0.972 | 0.107 | 0.028 | 0.053 | |

CFB at 16:00 | |||||

LS mean | 7.05 | 6.91 | 8.31 | 8.26 | 7.12 |

Difference (95% CI) | −0.07 (−1.13 to 1.00) | −0.22 (−1.27 to 0.84) | 1.19 (0.14 to 2.25) | 1.14 (0.08 to 2.19) | |

p Value | 0.901 | 0.689 | 0.027 | 0.034 | |

Day 28 (Visit 6) | |||||

Mean diurnal CFB | |||||

LS mean | 7.81 | 8.26 | 9.00 | 8.93 | 7.77 |

Difference (95% CI) | 0.05 (−0.82 to 0.91) | 0.50 (−0.36 to 1.36) | 1.23 (0.37 to 2.10) | 1.16 (0.29 to 2.03) | |

p Value | 0.913 | 0.258 | 0.005 | 0.009 | |

CFB at 08:00 | |||||

LS mean | 8.45 | 8.83 | 9.59 | 9.64 | 8.64 |

Difference (95% CI) | −0.18 (−1.18 to 0.82) | 0.19 (−0.80 to 1.19) | 0.96 (−0.04 to 1.95) | 1.01 (0.00 to 2.01) | |

p Value | 0.720 | 0.703 | 0.059 | 0.049 | |

CFB at 12:00 | |||||

LS mean | 7.83 | 8.12 | 9.02 | 8.74 | 7.66 |

Difference (95% CI) | 0.17 (−0.80 to 1.14) | 0.47 (−0.49 to 1.42) | 1.36 (0.40 to 2.32) | 1.08 (0.12 to 2.05) | |

p Value | 0.730 | 0.340 | 0.006 | 0.028 | |

CFB at 16:00 | |||||

LS mean | 7.17 | 7.79 | 8.59 | 8.44 | 6.94 |

Difference (95% CI) | 0.23 (−0.71 to 1.17) | 0.86 (−0.07 to 1.79) | 1.66 (0.73 to 2.59) | 1.50 (0.57 to 2.44) | |

p Value | 0.629 | 0.070 | 0.001 | 0.002 | |

Day 29 (Visit 7) | |||||

Mean diurnal CFB | |||||

LS mean | 6.19 | 6.17 | 7.21 | 6.87 | 6.25 |

Difference (95% CI) | −0.07 (−1.03 to 0.90) | −0.08 (−1.03 to 0.87) | 0.95 (−0.00 to 1.91) | 0.62 (−0.34 to 1.57) | |

p Value | 0.894 | 0.869 | 0.051 | 0.204 | |

CFB at 08:00 | |||||

LS mean | 7.01 | 6.75 | 7.73 | 7.43 | 6.94 |

Difference (95% CI) | 0.07 (−1.00 to 1.14) | −0.19 (−1.25 to 0.86) | 0.79 (−0.27 to 1.85) | 0.48 (−0.58 to 1.54) | |

p Value | 0.897 | 0.720 | 0.144 | 0.369 | |

CFB at 12:00 | |||||

LS mean | 6.03 | 6.08 | 7.14 | 6.91 | 6.13 |

Difference (95% CI) | −0.09 (−1.16 to 0.97) | −0.04 (−1.09 to 1.01) | 1.02 (−0.04 to 2.07) | 0.79 (−0.27 to 1.84) | |

p Value | 0.862 | 0.937 | 0.058 | 0.144 | |

CFB at 16:00 | |||||

LS mean | 5.47 | 5.69 | 6.75 | 6.11 | 5.67 |

Difference (95% CI) | −0.20 (−1.28 to 0.89) | 0.02 (−1.03 to 1.08) | 1.09 (0.03 to 2.14) | 0.45 (−0.62 to 1.51) | |

p Value | 0.721 | 0.965 | 0.045 | 0.411 |

IOP reduction=IOP value at baseline minus IOP value postbaseline. The reference treatment was latanoprost.

*Results obtained from an ANCOVA model with treatment effect and baseline IOP. ANCOVA, analysis of covariance; CFB, change from baseline; IOP, intraocular pressure; LBN, latanoprostene bunod; LS, least squares.