Changes in macular pigment optical density during supplementation in patients with early age-related macular degeneration
| Time | Placebo (n=28) | 10 mg lutein (n=26) | 20 mg lutein (n=27) | Lutein+zeaxanthin (n=27) | p Value | ||
|---|---|---|---|---|---|---|---|
| Group | Time | Time×group | |||||
| Baseline | 0.315±0.144 | 0.307±0.142 | 0.315±0.122 | 0.320±0.118 | 0.072 | <0.001 | 0.046 |
| 24 weeks | 0.310±0.102 | 0.353±0.125 | 0.395±0.120** | 0.356±0.150 | |||
| 48 weeks | 0.316±0.110 | 0.371±0.188 | 0.424±0.142*** | 0.384±0.125* | |||
| 2 years | 0.324±0.163 | 0.442±0.127*** | 0.441±0.133*** | 0.383±0.149* | |||
Values are density units and are expressed as mean±SD.
Mean values were significantly different from baseline within the same group: *p<0.05, **p<0.01, ***p<0.001.