Ocular adverse event rates from hypothetical randomised controlled trial scenarios comparing a 12-week course of two IOP-lowering drugs for open-angle glaucoma
| Scenario | Drug A n/N (%) | Drug B n/N (%) | Difference in percentages (95% CI) | p Value |
|---|---|---|---|---|
| 1 | 1/30 (3) | 8/30 (27) | −23 (−41 to −5) | 0.026 |
| 2 | 4/30 (13) | 10/30 (33) | −20 (−40 to 2) | 0.125 |
| 3 | 28/300 (9) | 45/300 (15) | −6 (−11 to −0.4) | 0.045 |
| 4 | 6/300 (2) | 9/300 (3) | −1 (−4 to 2) | 0.603 |
Calculations were carried out in Stata6 using command csi and rdcii; the p value is from a two-sided Fisher's exact test and the CI for the percentage difference is from Newcombe's Method 107.
IOP, intraocular pressure; n, number of adverse events; N, number of patients.