Multivariate analysis of risk factors for mean TISA750 change from baseline to follow-up*
| Baseline characteristic† | Regression coefficient | 95% CI | p Value |
|---|---|---|---|
| Age | −0.00008 | −0.0009 to 0.0007 | 0.853 |
| Gender | 0.007 | −0.003 to 0.017 | 0.166 |
| AxL (mm) | 0.005 | 0.000 to 0.010 | 0.037 |
| ACD (mm) | 0.008 | −0.017 to 0.032 | 0.534 |
| LV (µm) | −0.000004 | −0.00003 to 0.00002 | 0.774 |
| Mean IT2000 (mm) | 0.013 | −0.062 to 0.087 | 0.740 |
| Mean ICURV (mm) | −0.06 | −0.107 to −0.013 | 0.013 |
R2=0.146.
Significant difference noted as p<0.05.
*TISA750 change was defined as baseline TISA750 minus follow-up TISA750. The mean change between the nasal and temporal quadrant was used.
†The variables included in the final multivariate models are age, gender, AxL, ACD, LV, mean IT2000 and mean ICURV. Addition of centiles of ACD and LV did not show any significant association.
ACD, anterior chamber depth; AxL, axial length; ICURV, iris curvature; IT, iris thickness; LV, lens vault; TISA, trabecular -iris space area.