Univariate analysis of risk factors for TISA750 change (in mm) from baseline to 4 years follow-up*
| Baseline characteristic | Regression coefficient (β) | 95% CI† | p Value |
|---|---|---|---|
| Age (years) | −0.001 | −0.001 to −0.00005 | 0.167 |
| Ethnicity (reference=non-Chinese) | −0.002 | −0.018 to 0.013 | 0.755 |
| Gender (reference=male) | 0.003 | −0.007 to 0.013 | 0.518 |
| Clinical measurements | |||
| AxL (mm) | 0.009 | 0.005 to 0.013 | <0.0001 |
| ACD‡ (mm) | 0.033 | 0.016 to 0.050 | <0.0001 |
| IOP (mm Hg) | −0.02 | −0.004 to −0.0001 | 0.090 |
| AS-OCT measurements | |||
| ACA (mm2) | 0.003 | 0.001 to 0.005 | <0.001 |
| ACV (mm3) | 0.001 | 0.0001 to 0.001 | 0.017 |
| LV (µm)‡ | 1.542 | 1.00001 to 5.589 | 0.003 |
| Nasal quadrant | |||
| AOD750 (mm) | 0.083 | 0.052 to 0.114 | <0.001 |
| TISA750 (mm) | 0.157 | 0.092 to 0.221 | <0.001 |
| IT2000 (mm) | 0.081 | 0.015 to 0.148 | 0.016 |
| IAREA (mm2) | 0.014 | −0.006 to 0.035 | 0.173 |
| ICURV (mm) | −0.084 | −0.128 to −0.039 | <0.0001 |
| Temporal quadrant | |||
| AOD750 (mm) | 0.081 | 0.054 to 0.108 | <0.001 |
| TISA750 (mm) | 0.146 | 0.091 to 0.201 | <0.001 |
| IT2000 (mm) | 0.010 | −0.052 to 0.072 | 0.75 |
| IAREA (mm2) | 0.003 | −0.017 to 0.024 | 0.742 |
| ICURV (mm) | −0.052 | −0.080 to −0.024 | <0.001 |
Significant difference noted as p<0.05.
*TISA750 change was defined as baseline TISA750 minus follow-up TISA750. The mean change combining the nasal and temporal quadrants was used.
†Adjusted for age and sex (except for age and sex categories, which are unadjusted).
‡Highest centiles of ACD and LV showed significant associations (β=0.029; p<0.0001 and β=−0.024; p=0.002, respectively).
ACA, anterior chamber area; ACD, anterior chamber depth; ACV, anterior chamber volume; AOD, angle opening distance; AS-OCT, anterior segment optical coherence tomography; AxL, axial length; CDR, cup:disc ratio; IAREA, iris area; ICURV, iris curvature; IOP, intraocular pressure; IT, iris thickness; LV, lens vault; TISA, trabecular iris space area.