Table 2

Characteristics and outcomes of clinical reports on allogeneic serum eye drop therapy

Chiang et al2536 eyesPED100% allogeneic serum hourly (monotherapy)15 (42%) of PEDs healed within 2 weeksNone
Chiang et al302 patientsGVHD-related DES100% allogeneic serum hourly (monotherapy)Patient 1: improved symptoms, TBUT and corneal staining at 2 weeks;
Patient 2: improved symptoms, resolution of filamentous keratopathy at 1 week
Na and Kim1716 patientsGVHD-related DES20% allogeneic serum 6–8 times/day (with PFAT)Improved OSDI score, corneal staining, impression cytology grade and tear osmolarity at 4 weeksNone
Harritshøj et al5120 DES patients, 14 PED eyesPED and DES20% allogeneic serum (frequency not specified)80% (16) DES patients with improved symptoms and corneal staining, no subjective or objective effects on PED group at 4 weeksNone
  • DES, dry eye syndrome; GVHD, graft-versus-host disease; OSDI, Ocular Surface Disease Index; PED, persistent epithelial defect; PFAT, preservative-free artificial tears; TBUT, tear break-up time.