Table 3

The association of IL23R/C1orf141 and ADO/ZNF365/EGR2 with VKH syndrome

ChrGeneSNPAlleleStageMAF (Case/control)p Valuepc ValueOR (95% CI)
1IL23R/C1orf141rs77258390AChinese Singaporean18.8/3.78.49×10−51.69×10−45.9 (2.2 to 15.9)
Non-Han Chinese25.0/14.20.056NS2.0 (0.9 to 4.1)
Thai6.2/3.00.335NS2.1 (0.4 to 9.8)
Korean5.9/4.50.665NS1.2 (0.4 to 4.0)
1IL23R/C1orf141rs3762318CChinese Singaporean20.3/4.81.46×10−42.92×10−45.0 (2.0 to 12.5)
Non-Han Chinese27.6/15.80.045NS2.0 (1.0 to 4.1)
Thai7.4/4.50.429NS1.6 (0.4 to 6.1)
Korean5.9/4.50.665NS1.2 (0.4 to 4.0)
1IL23R/C1orf141rs78597810CChinese Singaporean18.8/3.78.49×10−51.69×10−45.9 (2.2 to 15.9)
Non-Han Chinese25.7/14.20.045NS2.0 (1.0 to 4.3)
Thai6.2/4.50.631NS1.3 (0.3 to 5.1)
Korean5.9/4.50.665NS1.2 (0.4 to 4.0)
1IL23R/C1orf141rs12568393AChinese Singaporean18.8/3.78.49×10−51.69×10−45.9 (2.2 to 15.9)
Non-Han Chinese25.0/13.80.049NS2.0 (0.9 to 4.3)
Thai6.2/4.50.631NS1.3 (0.3 to 5.1)
Korean5.9/4.50.665NS1.2 (0.4 to 4.0)
1IL23R/C1orf141rs12561798CChinese Singaporean18.8/3.78.49×10−51.69×10−45.9 (2.2 to 15.9)
Non-Han Chinese25.0/14.20.056NS2.0 (0.9 to 4.1)
Thai6.2/4.50.631NS1.3 (0.3 to 5.1)
Korean5.9/4.50.665NS1.2 (0.4 to 4.0)
1IL23R/C1orf141rs76436269AChinese Singaporean18.8/3.78.49×10−51.69×10−45.9 (2.2 to 15.9)
Non-Han Chinese25.0/14.20.056NS2.0 (0.9 to 4.1)
Thai6.2/4.50.631NS1.3 (0.3 to 5.1)
Korean5.9/4.50.665NS1.2 (0.4 to 4.0)
1IL23R/C1orf141rs78377598TChinese Singaporean18.8/5.31.02×10−32.04×10−34.1 (1.6 to 10.1)
Non-Han Chinese26.3/14.20.034NS2.1 (1.0 to 4.4)
Thai6.2/4.50.631NS1.3 (0.3 to 5.1)
Korean5.9/4.50.665NS1.2 (0.4 to 4.0)
1IL23R/C1orf141rs117633859GChinese Singaporean21.7/5.93.50×10−47.00×10−44.4 (1.9 to 10.4)
Non-Han Chinese27.1/13.90.028NS2.3 (1.1 to 4.9)
Thai6.3/4.70.65NS1.4 (0.4 to 5.1)
Korean7.4/5.20.50NS1.5 (0.5 to 4.4)
1IL23R/C1orf141rs1884444GChinese Singaporean43.8/30.30.049NS1.7 (0.9 to 3.2)
Non-Han Chinese56.6/45.80.143NS1.5 (0.8 to 2.7)
Thai36.4/30.30.379NS1.3 (0.7 to 2.4)
Korean35.3/40.00.504NS0.8 (0.4 to 1.4)
10ADO/ZNF365/EGR2rs10995276AChinese Singaporean12.5/9.60.506NS1.3 (0.5 to 3.2)
Non-Han Chinese21.1/14.20.209NS1.6 (0.7 to 3.4)
Thai17.9/7.60.047NS2.6 (0.9 to 7.2)
Korean16.2/14.50.738NS1.1 (0.5 to 2.4)
10ADO/ZNF365/EGR2rs442309TChinese Singaporean20.3/22.30.734NS0.8 (0.4 to 1.7)
Non-Han Chinese31.6/30.80.913NS1.0 (0.5 to 1.9)
Thai34.6/18.20.0140.0282.3 (1.1 to 4.8)
Korean39.7/33.00.282NS1.4 (0.7 to 2.6)
10ADO/ZNF365/EGR2rs224048TChinese Singaporean20.3/22.30.734NS0.8 (0.4 to 1.7)
Non-Han Chinese31.6/30.50.875NS1.0 (0.5 to 1.9)
Thai34.6/18.20.0140.0282.3 (1.1 to 4.8)
Korean39.7/33.00.282NS1.4 (0.7 to 2.6)
10ADO/ZNF365/EGR2rs224052AChinese Singaporean20.3/22.30.734NS0.8 (0.4 to 1.7)
Non-Han Chinese31.6/30.50.875NS1.0 (0.5 to 1.9)
Thai34.6/18.20.0140.0282.3 (1.1 to 4.8)
Korean39.7/33.00.282NS1.4 (0.7 to 2.6)
10ADO/ZNF365/EGR2rs224057AChinese Singaporean20.3/22.30.734NS0.8 (0.4 to 1.7)
Non-Han Chinese31.6/30.50.875NS1.0 (0.5 to 1.9)
Thai34.6/18.20.0140.0282.3 (1.1 to 4.8)
Korean39.7/33.00.282NS1.4 (0.7 to 2.6)
10ADO/ZNF365/EGR2rs224058TChinese Singaporean20.3/22.30.734NS0.8 (0.4 to 1.7)
Non-Han Chinese31.6/30.80.913NS1.0 (0.5 to 1.9)
Thai34.6/18.20.0140.0282.3 (1.1 to 4.8)
Korean39.7/33.00.282NS1.4 (0.7 to 2.6)
10ADO/ZNF365/EGR2rs10995307CChinese Singaporean21.9/26.10.504NS0.7 (0.4 to 1.5)
Non-Han Chinese30.3/30.20.989NS1.0 (0.5 to 1.8)
Thai32.7/25.80.302NS1.4 (0.7 to 2.6)
Korean36.8/30.50.342NS1.3 (0.7 to 2.3)
  • Chr, chromosome; NS, no significance; MAF, frequency of minor allele; pc value, p Value after Bonferroni correction; OR: OR for minor allele; SNP, single nucleotide polymorphism; VKH, Vogt–Koyanagi–Harada.