First author | Type of study | Total n | Mean baseline IOP (mm Hg) | Mean final IOP (mm Hg) | % IOP decrease | Mean # decrease in medication | Length of study (months) |
---|---|---|---|---|---|---|---|
Standalone Trabectome outcomes | |||||||
POAG of Ting13 | Prospective | 450 | 26 | 17 | 34 | 0.57 | 12 |
PXG of Ting13 | Prospective | 67 | 29 | 16 | 44 | 0.88 | 12 |
Jea14 | Retrospective | 115 | 28 | 17 | 41 | 1 | 30 |
Minckler15 | Prospective | 1151 | 26 | 17 | 36 | 1.7 | 60 |
Ahuja16 | Retrospective | 88 | 26 | 13 | 50 | 0.3 | 48 |
Maeda17 | Prospective | 80 | 27 | 18 | 33 | 1.7 | 12 |
Werth18 | Prospective | 92 | 20 | 15 | 23 | Not reported | 12 |
Combined phacoemulsification with Trabectome outcomes | |||||||
Francis19 | Prospective | 304 | 20 | 17 | 17 | 1.22 | 21 |
POAG of Ting13 | Prospective | 263 | 20 | 16 | 22 | 0.75 | 12 |
PXG of Ting13 | Prospective | 45 | 22 | 14 | 35 | 0.96 | 12 |
Minckler15 | Prospective | 681 | 20 | 16 | 21 | 0.87 | 36 |
Francis20 | Prospective | 89 | 22 | 15 | 30 | 1 | 12 |
Ahuja16 | Retrospective | 158 | 19 | 12 | 39 | 0.5 | 45 |
Klamann21 | Retrospective | 27 | 23 | 14 | 40 | 0.29 | 12 |
Klamann12 | Retrospective | 74 | 21 | 13 | 37.5 | 0.12 | 6 |
Francis22 | Prospective | 114 | 22 | 15 | 31 | 1 | 24 |
Werth18 | Prospective | 30 | 21 | 19 | 21 | Not reported | 12 |
From table 1, it can be seen that AIT can be expected to lower the IOP by approximately 36% to a final average IOP around 16 mm Hg. The overall mean baseline IOP for AIT was 26.71±1.34 mm Hg and decreased by 10.5±1.9 mm Hg (39% decrease) on 0.99±0.54 fewer medications. For phaco-AIT, the mean baseline IOP of 21±1.31 mm Hg decreased by 6.24±1.98 mm Hg (27% decrease) on 0.76±0.35 fewer medications.
AIT, ab-interno trabeculectomy; IOP, intraocular pressure; POAG, paediatric open-angle glaucoma; PXG, pseudoexfoliation glaucoma.