Mean improvement in visual acuity, number of injections and change in CRT at 12 months in the T&E group versus the as needed group
| T&E Regimen | PRN Regimen | PRN Regimen (RCT) | Difference (Mann-Whitney's test) PRN/PRN RCT | |
|---|---|---|---|---|
| Weighted mean/mean ETDRS letters gained | 9.17/10.4 (SD=3.8, CI 7.4 to 13) | 3.5/5.4 (SD=4.5, CI 4.28 to 6.43) | 5.1/5.8 (SD=2.7, CI 4.4 to 7.2) | p=0.0006/0.0051 Significant |
| Weighted mean/mean injections in 1 year | 8.34/8.09 (SD=0.66, CI 7.6 to 8.6) | 5.3/5.6 (SD=0.99, CI 5.32 to 5.79) | 6.6/6.5 (SD=0.88, CI 6.0 to 6.9) | p<0.0001/0.0002 Significant |
| Weighted mean/mean change in CRT | 85.71/87.7 (SD=27.67, CI 64.58 to 110.8) | 99.2/100.32 (SD=40.69, CI 89.1 to 111.54) | 122.2/110 (SD=32, CI 90 to 120) | p=0.41/0.1784 Not Significant |
Data for the RCT employing an as needed regimen are included in a separate column.
The significance level was set at p<0.05.
CRT, central retinal thickness; RCT, randomised clinical trial; PRN, pro re nata; T&E, treat and extend.