Table 2

Relationship between MP and visual function using baseline data in the Central Retinal Enrichment Supplementation Trial (CREST) age-related macular degeneration study

VariablesMP at 0.25MP at 0.5MP at 1.0MP at 1.75
BCVAr=0.241, p=0.009r=0.243, p=0.008r=0.210, p=0.022r=0.107, p=0.248
Letter CS (cpd)
 1.2r=0.101, p=0.278r=0.113, p=0.225r=0.219, p=0.017r=0.102, p=0.272
 2.4r=0.094, p=0.310r=0.116, p=0.210r=0.171, p=0.064r=0.020, p=0.829
 6r=0.166, p=0.073r=0.157, p=0.089r=0.153, p=0.098r=0.016, p=0.859
 9.6r=0.113, p=0.221r=0.096, p=0.302r=0.082, p=0.375r=−0.014, p=0.883
 15.15r=0.106, p=0.257r=0.106, p=0.256r=0.080, p=0.393r=0.037, p=0.690
CSmesopic (cpd)
 1.5r=0.103, p=0.267r=0.123, p=0.185r=0.194, p=0.035r=0.131, p=0.157
 3r=0.139, p=0.133r=0.217, p=0.018r=0.165, p=0.074r=0.038, p=0.680
 6r=0.169, p=0.067r=0.203, p=0.028r=0.148, p=0.111r=0.111, p=0.230
 12r=0.209, p=0.023r=0.220, p=0.017r=0.209, p=0.023r=0.159, p=0.086
 18r=0.175, p=0.058r=0.170, p=0.066r=0.071, p=0.447r=0.228, p=0.013
CSphotopic (cpd)
 1.5r=−0.002, p=0.987r=0.050, p=0.589r=0.097, p=0.295r=−0.025, p=0.787
 3r=0.091, p=0.326r=0.162, p=0.079r=0.137, p=0.138r=0.125, p=0.178
 6r=0.168, p=0.069r=0.243, p=0.008r=0.194, p=0.036r=0.075, p=0.422
 12r=0.259, p=0.005r=0.290, p=0.001r=0.238, p=0.009r=0.169, p=0.068
 18r=0.123, p=0.186r=0.144, p=0.119r=0.067, p=0.468r=0.062, p=0.502
GDmesopic (cpd)
 1.5r=0.051, p=0.580r=0.068, p=0.463r=0.069, p=0.461r=0.002, p=0.983
 3r=0.077, p=0.407r=0.113, p=0.225r=0.070, p=0.454r=−0.010, p=0.916
 6r=0.041, p=0.656r=0.098, p=0.293r=0.032, p=0.733r=−0.096, p=0.303
 12r=0.029, p=0.758r=0.060, p=0.520r=0.067, p=0.474r=−0.034, p=0.713
 18r=0.047, p=0.611r=0.080, p=0.390r=0.042, p=0.654r=0.031, p=0.740
GDphotopic (cpd)
 1.5r=0.051, p=0.580r=0.083, p=0.374r=0.081, p=0.382r=0.061, p=0.515
 3r=0.164, p=0.076r=0.256, p=0.005r=0.231, p=0.012r=0.153, p=0.098
 6r=0.233, p=0.011r=0.242, p=0.008r=0.186, p=0.043r=0.116, p=0.211
 12r=0.222, p=0.016r=0.225, p=0.014r=0.164, p=0.077r=0.085, p=0.359
 18r=0.166, p=0.073r=0.180, p=0.051r=0.070, p=0.450r=0.069, p=0.458
PRTr=0.073, p=0.433r=0.153, p=0.097r=0.068, p=0.464r=0.001, p=0.990
 RAcuityr=−0.183, p=0.047r=−0.187, p=0.042r=−0.113, p=0.152r=−0.056, p=0.547
 Mean RSr=0.177, p=0.056r=0.170, p=0.065r=0.222, p=0.016r=0.132, p=0.153
 Max RSr=0.135, p=0.146r=0.119, p=0.201r=0.164, p=0.076r=0.040, p=0.664
 VFQ_Tscorer=0.188, p=0.042r=0.132, p=0.155r=0.124, p=0.181r=0.025, p=0.787
  • Bold typeface signifies statistically significant p value (p<0.05).

  • BCVA, best corrected visual acuity measured with Thompson Test Chart 2000 Xpert and recorded in visual acuity rating (VAR); cpd, cycles per degrees; CS, contrast sensitivity; CSmesopic, contrast sensitivity measured under nighttime conditions (3.0 candela per metre square (cd/m2)) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; CSphotopic, contrast sensitivity measured under daytime conditions (85 cd/m2) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; GD, glare disability; GDmesopic, glare disability measured under nighttime conditions (28 Lux) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; GDphotopic, glare disability measured under daytime conditions (135 Lux) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; LetterCS, letter contrast sensitivity assessed using Thompson Test Chart 2000 PRO and recorded in logarithm of contrast sensitivity (LogCS) units; maxRS, maximum reading speed; meanRS, mean reading speed calculated as the average of the reading speed scores recorded for each of the standardised sentences; MP, macular pigment measured at 0.25°, 0.5°, 1.0° and 1.75° eccentricities using customised heterochromatic flicker photometry; p, level of statistical significance set at p<0.05; PRT, photostress recovery time recorded in seconds (reading assessed using the English version of the standardised Radner reading chart); r, Pearson's correlation coefficient; RAcuity, reading acuity (Reading acuity is recorded in logarithm of the reading acuity determination (LogRAD). The formula (logRAD+total number of incorrectly read syllables ×0.005) is used to calculate the LogRAD-score.); RS, reading speed (the time taken to read the number of words in a sentence) measured in words per minute (w/min) with a stop watch for each standardised sentence (14 words×60 s divided by reading time in seconds); SVF, subjective visual function assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25; scores range from 0 (worst) to 100 (best)); VFQ_Tscore, NEI VFQ-25 overall vision score.