Table 2

Overall change in structural and functional progression measurements from baseline to 4 years

 Baseline4-yearChange from baseline to 4 years
NMean (95% CI)NMean (95% CI)Mean (95% CI)p Value
IOP11216.39 (15.06 to 17.72)8215.85 (14.40 to 17.31)−0.54 (−1.60 to 0.52)0.314
MD112−3.53 (4.66 to −2.41)83−4.91 (−6.31 to −3.50)−1.37 (−2.11 to −0.63)0.000*
AGIS score1121.62 (0.97 to 2.48)832.44 (1.51 to 3.71)0.62 (0.29 to 0.91)0.001*
RNFL average thickness11273.36 (68.41 to 78.32)8373.80 (68.44 to 79.17)0.44 (−2.23 to 3.11)0.744
Cup/disc horizontal ratio1120.70 (0.65 to 0.75)830.76 (0.71 to 0.81)0.06 (0.03 to 0.10)0.000*
Cup/disc vertical ratio1120.687 (0.638 to 0.736)830.725 (0.675 to 0.774)0.038 (0.006 to 0.070)0.019*
  • Accurate IOP with applanation was unable to be obtained at 4-year follow-up in one patient.

  • *Denotes a statistically significant difference between baseline and 4-year follow-up for all patients (p<0.05).

  • AGIS, Advanced Glaucoma Intervention Study; IOP, intraocular pressure; MD, mean deviation; RNFL, retinal nerve fibre layer.