Table 3.6

Class: Alpha-2 SELECTIVE ADRENERGIC AGONISTS

CompoundMode of actionIOP reductionContra-indicationsSide effects
Apraclonidine 0.5-1.0%Decreases aqueous humour production25-35%Local: Lid retraction, conjunctival blanching, limited mydriasis (apraclonidine), allergic blepharoconjuntivitis, periocular contact dermatitis, allergy or delayed hypersensitivity (apraclonidine and clonidine >brimonidine)
Brimonidine 0.2%Decreases aqueous humour production and increases uveo-scleral out?ow
Alpha-2- selectiveClonidine 0.125 -0.5%Decreases aqueous humour production18-25%Oral monoamine oxidase (MAO) inhibitor users Pediatric age Very low body weight in adultsSystemic: Dry mouth and nose (apraclonidine). Systemic hypotension, bradycardia (clonidine), fatigue, sleepiness (brimonidine)