Table 3

Results of meta-analysis for polymorphisms and treatment response of nAMD

					FEM or REM*		Heterogeneity
Gene	Polymorphism	No. of cohorts		Genetic model	OR (95% CI)	p	P (Q)	I² (%)	Egger's test (p)
VEGF-A	Rs699947 A>C	Overall		A vs C	1.030 (0.915 to 1.161)	0.622	0.370	7.8	0.282
				AA vs CC	1.078 (0.842 to 1.378)	0.553	0.133	35.6	0.349
				AC vs CC	1.089 (0.894 to 1.326)	0.156	0.559	0.0	0.161
				AA vs AC+CC	1.165 (0.787 to 1.726)	0.445	0.010	60.4	0.161
				AA+AC vs CC	1.083 (0.898 to 1.306)	0.403	0.887	0.0	0.281
		Sub-analysis by ethnicity	Caucasian	A vs C	1.008 (0.888 to 1.143)	0.906	0.372	7.5	n.a
				AA vs CC	0.983 (0.759 to 1.273)	0.897	0.407	3.0	n.a
				AC vs CC	1.168 (0.942 to 1.448)	0.156	0.768	0.0	n.a
				AA vs AC+CC	0.983 (0.707 to 1.368)	0.930	0.105	41.0	n.a
				AA+AC vs CC	1.110 (0.905 to 1.360)	0.316	0.857	0.0	n.a
			East Asia	A vs C	1.238 (0.862 to 1.777)	0.247	n.a	n.a	n.a
				AA vs CC	3.000 (1.190 to 7.566)	0.020	n.a	n.a	n.a
				AC vs CC	0.735 (0.443 to 1.221)	0.235	n.a	n.a	n.a
				AA vs AC+CC	3.482 (1.427 to 8.496)	0.006	n.a	n.a	n.a
				AA+AC vs CC	0.947 (0.586 to 1.528)	0.822	n.a	n.a	n.a
	Rs 699946 A>G	Overall		A vs G	1.016 (0.863 to 1.198)	0.846	0.332	9.3	n.a
				AA vs GG	1.031 (0.665 to 1.600)	0.890	0.253	27.3	0.841
				AG vs GG	1.066 (0.687 to 1.654)	0.776	0.407	0.0	0.408
				AA vs AG+GG	1.013 (0.828 to 1.239)	0.900	0.497	0.0	0.657
				AA+AG vs GG	1.051 (0.692 to 1.597)	0.815	0.294	18.2	0.685
		Sub-analysis by ethnicity	Caucasian	A vs G	1.039 (0.862 to 1.254)	0.686	0.159	49.5	n.a
				AA vs GG	1.114 (0.629 to 1.927)	0.712	0.103	62.5	n.a
				AG vs GG	1.081 (0.600 to 1.947)	0.795	0.179	44.5	n.a
				AA vs AG+GG	1.039 (0.834 to 1.295)	0.733	0.298	7.6	n.a
				AA+AG vs GG	1.103 (0.625 to 1.944)	0.735	0.119	58.9	n.a
			East Asia	A vs G	0.944 (0.672 to 1.327)	0.739	n.a	n.a	n.a
				AA vs GG	0.918 (0.458 to 1.841)	0.810	n.a	n.a	n.a
				AG vs GG	1.047 (0.540 to 2.028)	0.892	n.a	n.a	n.a
				AA vs AG+GG	0.888 (0.539 to 1.464)	0.642	n.a	n.a	n.a
				AA+AG vs GG	0.991 (0.531 to 1.848)	0.978	n.a	n.a	n.a
	Rs 833069 C>T	Caucasian		C vs T	0.961 (0.827 to 1.115)	0.598	0.650	0.0	0.514
				CC vs TT	0.824 (0.591 to 1.148)	0.253	0.790	0.0	0.306
				CT vs TT	1.088 (0.880 to 1.347)	0.435	0.313	14.0	0.306
				CC vs CT+TT	0.795 (0.582 to 1.085)	0.149	0.728	0.0	0.496
				CC+CT vs TT	1.026 (0.839 to 1.255)	0.803	0.412	0.0	0.996
	Rs 833061 C>T	Overall		C vs T	1.266 (0.983 to 1.631)	0.067	0.406	0.0	0.882
				CC vs TT	2.222 (1.252 to 3.944)	0.006	0.292	19.6	0.326
				CT vs TT	2.537 (1.478 to 4.356)	0.001	0.227	30.9	0.882
				CC vs CT+TT	2.362 (1.414 to 3.946)	0.001	0.214	33.1	0.145
				CC+CT vs TT	1.029 (0.718 to 1.476)	0.876	0.758	0.0	0.765
		Sub-analysis by ethnicity	Caucasian	C vs T	1.302 (0.912 to 1.859)	0.146	0.239	30.1	n.a
				CC vs TT	1.845 (0.882 to 3.861)	0.104	0.200	37.9	n.a
				CT vs TT	1.989 (1.011 to 3.910)	0.046	0.204	37.0	n.a
				CC vs CT+TT	1.937 (1.025 to 3.661)	0.042	0.163	44.9	n.a
				CC+CT vs TT	1.136 (0.655 to 1.969)	0.649	0.618	0.0	n.a
			East Asia	C vs T	1.231 (0.859 to 1.763)	0.258	n.a	n.a	n.a
				CC vs TT	2.903 (1.150 to 7.330)	0.024	n.a	n.a	n.a
				CT vs TT	3.849 (1.522 to 9.733)	0.004	n.a	n.a	n.a
				CC vs CT+TT	3.339 (1.369 to 8.145)	0.008	n.a	n.a	n.a
				CC+CT vs TT	0.955 (0.592 to 1.541)	0.850	n.a	n.a	n.a
	Rs 2146323 A>C	Caucasian		A vs C	1.000 (0.859 to 1.164)	1.000	0.701	0.0	0.534
				AA vs CC	0.909 (0.644 to 1.282)	0.585	0.526	0.0	0.465
				AC vs CC	1.103 (0.888 to 1.369)	0.375	0.903	0.0	0.356
				AA vs AC+CC	0.867 (0.627 to 1.199)	0.389	0.434	0.0	0.500
				AA+AC vs CC	1.061 (0.863 to 1.304)	0.574	0.902	0.0	0.277
	Rs 1413711 T>C	Caucasian		T vs C	0.961 (0.832 to 1.109)	0.583	0.635	0.0	n.a
				TT vs CC	0.912 (0.683 to 1.216)	0.530	0.600	0.0	0.456
				TC vs CC	1.199 (0.940 to 1.531)	0.144	0.688	0.0	0.456
				TT vs TC+CC	0.811 (0.638 to 1.032)	0.089	0.256	26.7	0.972
				TT+TC vs CC	1.096 (0.871 to 1.379)	0.434	0.896	0.0	0.613
	Rs 2010963 C>G	Caucasian		C vs G	0.994 (0.852 to 1.161)	0.943	0.892	0.0	0.229
				CC vs GG	0.722 (0.340 to 1.535)	0.398	0.040	68.9	0.242
				CG vs GG	0.874 (0.520 to 1.470)	0.612	0.025	72.9	0.871
				CC vs CG+GG	0.831 (0.604 to 1.144)	0.257	0.773	0.0	0.749
CC+CG vs GG				1.075 (0.871 to 1.327)	0.501	0.668	0.0	0.416
Rs1570360 A>G	Caucasian		A vs G	1.378 (0.318 to 5.973)	0.668	0.007	86.1	n.a
			AA vs GG	1.895 (0.046 to 77.497)	0.736	0.018	82.0	n.a
			AG vs GG	1.494 (0.269 to 8.295)	0.646	0.148	52.3	n.a
			AA vs AG+GG	1.241 (0.127 to 12.115)	0.852	0.050	74.0	n.a
			AA+AG vs GG	1.932 (0.169 to 22.029)	0.596	0.042	75.9	n.a
VEGFR 2	Rs 2071559 A>G	Caucasian		A vs G	1.018 (0.885 to 1.171)	0.805	0.750	0.0	0.475
				AA vs GG	1.025 (0.775 to 1.355)	0.862	0.865	0.0	0.475
				AG vs GG	0.998 (0.790 to 1.261)	0.985	0.139	45.4	0.699
				AA vs AG+GG	1.040 (0.821 to 1.318)	0.744	0.941	0.0	0.319
				AA+AG vs GG	1.010 (0.810 to 1.258)	0.933	0.239	28.9	0.156

Bold text highlights positive results.
*If the p value for Q-statistic was >0.10 or the I² value was ≥50%, a REM was used, otherwise a FEM was adopted.
FEM, fixed-effects model; n.a, not available; nAMD, neovascular age-related macular degeneration; REM, random-effects model; VEGF-A, vascular endothelial growth factor A; VEGFR, vascular endothelial growth factor receptor.