Table 3

Results of meta-analysis for polymorphisms and treatment response of nAMD

FEM or REM*Heterogeneity
GenePolymorphismNo. of cohortsGenetic modelOR (95% CI)pP (Q)I2 (%)Egger's test (p)
VEGF-ARs699947
A>C
Overall A vs C1.030 (0.915 to 1.161)0.6220.3707.80.282
AA vs CC1.078 (0.842 to 1.378)0.5530.13335.60.349
AC vs CC1.089 (0.894 to 1.326)0.1560.5590.00.161
AA vs AC+CC1.165 (0.787 to 1.726)0.4450.01060.40.161
AA+AC vs CC1.083 (0.898 to 1.306)0.4030.8870.00.281
Sub-analysis by ethnicityCaucasianA vs C1.008 (0.888 to 1.143)0.9060.3727.5n.a
AA vs CC0.983 (0.759 to 1.273)0.8970.4073.0n.a
AC vs CC1.168 (0.942 to 1.448)0.1560.7680.0n.a
AA vs AC+CC0.983 (0.707 to 1.368)0.9300.10541.0n.a
AA+AC vs CC1.110 (0.905 to 1.360)0.3160.8570.0n.a
East AsiaA vs C1.238 (0.862 to 1.777)0.247n.an.an.a
AA vs CC3.000 (1.190 to 7.566)0.020n.an.an.a
AC vs CC0.735 (0.443 to 1.221)0.235n.an.an.a
AA vs AC+CC3.482 (1.427 to 8.496)0.006n.an.an.a
AA+AC vs CC0.947 (0.586 to 1.528)0.822n.an.an.a
Rs 699946
A>G
Overall A vs G1.016 (0.863 to 1.198)0.8460.3329.3n.a
AA vs GG1.031 (0.665 to 1.600)0.8900.25327.30.841
AG vs GG1.066 (0.687 to 1.654)0.7760.4070.00.408
AA vs AG+GG1.013 (0.828 to 1.239)0.9000.4970.00.657
AA+AG vs GG1.051 (0.692 to 1.597)0.8150.29418.20.685
Sub-analysis by ethnicityCaucasianA vs G1.039 (0.862 to 1.254)0.6860.15949.5n.a
AA vs GG1.114 (0.629 to 1.927)0.7120.10362.5n.a
AG vs GG1.081 (0.600 to 1.947)0.7950.17944.5n.a
AA vs AG+GG1.039 (0.834 to 1.295)0.7330.2987.6n.a
AA+AG vs GG1.103 (0.625 to 1.944)0.7350.11958.9n.a
East AsiaA vs G0.944 (0.672 to 1.327)0.739n.an.an.a
AA vs GG0.918 (0.458 to 1.841)0.810n.an.an.a
AG vs GG1.047 (0.540 to 2.028)0.892n.an.an.a
AA vs AG+GG0.888 (0.539 to 1.464)0.642n.an.an.a
AA+AG vs GG0.991 (0.531 to 1.848)0.978n.an.an.a
Rs 833069
C>T
Caucasian C vs T0.961 (0.827 to 1.115)0.5980.6500.00.514
CC vs TT0.824 (0.591 to 1.148)0.2530.7900.00.306
CT vs TT1.088 (0.880 to 1.347)0.4350.31314.00.306
CC vs CT+TT0.795 (0.582 to 1.085)0.1490.7280.00.496
CC+CT vs TT1.026 (0.839 to 1.255)0.8030.4120.00.996
Rs 833061
C>T
Overall C vs T1.266 (0.983 to 1.631)0.0670.4060.00.882
CC vs TT2.222 (1.252 to 3.944)0.0060.29219.60.326
CT vs TT2.537 (1.478 to 4.356)0.0010.22730.90.882
CC vs CT+TT2.362 (1.414 to 3.946)0.0010.21433.10.145
CC+CT vs TT1.029 (0.718 to 1.476)0.8760.7580.00.765
Sub-analysis by ethnicityCaucasianC vs T1.302 (0.912 to 1.859)0.1460.23930.1n.a
CC vs TT1.845 (0.882 to 3.861)0.1040.20037.9n.a
CT vs TT1.989 (1.011 to 3.910)0.0460.20437.0n.a
CC vs CT+TT1.937 (1.025 to 3.661)0.0420.16344.9n.a
CC+CT vs TT1.136 (0.655 to 1.969)0.6490.6180.0n.a
East AsiaC vs T1.231 (0.859 to 1.763)0.258n.an.an.a
CC vs TT2.903 (1.150 to 7.330)0.024n.an.an.a
CT vs TT3.849 (1.522 to 9.733)0.004n.an.an.a
CC vs CT+TT3.339 (1.369 to 8.145)0.008n.an.an.a
CC+CT vs TT0.955 (0.592 to 1.541)0.850n.an.an.a
Rs 2146323
A>C
Caucasian A vs C1.000 (0.859 to 1.164)1.0000.7010.00.534
AA vs CC0.909 (0.644 to 1.282)0.5850.5260.00.465
AC vs CC1.103 (0.888 to 1.369)0.3750.9030.00.356
AA vs AC+CC0.867 (0.627 to 1.199)0.3890.4340.00.500
AA+AC vs CC1.061 (0.863 to 1.304)0.5740.9020.00.277
Rs 1413711
T>C
Caucasian T vs C0.961 (0.832 to 1.109)0.5830.6350.0n.a
TT vs CC0.912 (0.683 to 1.216)0.5300.6000.00.456
TC vs CC1.199 (0.940 to 1.531)0.1440.6880.00.456
TT vs TC+CC0.811 (0.638 to 1.032)0.0890.25626.70.972
TT+TC vs CC1.096 (0.871 to 1.379)0.4340.8960.00.613
Rs 2010963
C>G
Caucasian C vs G0.994 (0.852 to 1.161)0.9430.8920.00.229
CC vs GG0.722 (0.340 to 1.535)0.3980.04068.90.242
CG vs GG0.874 (0.520 to 1.470)0.6120.02572.90.871
CC vs CG+GG0.831 (0.604 to 1.144)0.2570.7730.00.749
CC+CG vs GG1.075 (0.871 to 1.327)0.5010.6680.00.416
Rs1570360
A>G
Caucasian A vs G1.378 (0.318 to 5.973)0.6680.00786.1n.a
AA vs GG1.895 (0.046 to 77.497)0.7360.01882.0n.a
AG vs GG1.494 (0.269 to 8.295)0.6460.14852.3n.a
AA vs AG+GG1.241 (0.127 to 12.115)0.8520.05074.0n.a
AA+AG vs GG1.932 (0.169 to 22.029)0.5960.04275.9n.a
VEGFR 2Rs 2071559
A>G
Caucasian A vs G1.018 (0.885 to 1.171)0.8050.7500.00.475
AA vs GG1.025 (0.775 to 1.355)0.8620.8650.00.475
AG vs GG0.998 (0.790 to 1.261)0.9850.13945.40.699
AA vs AG+GG1.040 (0.821 to 1.318)0.7440.9410.00.319
AA+AG vs GG1.010 (0.810 to 1.258)0.9330.23928.90.156
  • Bold text highlights positive results.

  • *If the p value for Q-statistic was >0.10 or the I2 value was ≥50%, a REM was used, otherwise a FEM was adopted.

  • FEM, fixed-effects model; n.a, not available; nAMD, neovascular age-related macular degeneration; REM, random-effects model; VEGF-A, vascular endothelial growth factor A; VEGFR, vascular endothelial growth factor receptor.