Table 2

Non-IgG4-RD orbital inflammations: group 2 (no. 1–12, idiopathic OID) and group 3 (no. 13–26, autoimmune orbital inflammation)

NoSiteSexRaceAgeHistologyTiss
involved
Syst IgG4-RDTiss IgGTiss IgG2Tiss IgG4IgG2:IgG (%)IgG4:IgG (%)IgG2:IgG4sIg G1sIg G2sIg G3sIg G4
1UKMCau35Chronic dacryoadenitisLacrimalNo2353411170.077.224.90.153.08
2UKFCau15Chronic dacryoadenitisLacrimalNo1443182130.178.044.651.221.34
3SGFM30Chronic inflammationLacrimalNo133308023600.388.494.472.131.47
4UKFCau53Chronic inflammation with granulomasOrbitalNo216762535123.049.14.90.40.2
5UKMCau36Chronic inflammationRectusNo44234540.068.76.781.390.54
6UKFInd51Chronic inflammationLacrimalNo270156225880.0710.75.01.20.47
7UKMCau52Chronic inflammationLacrimalNo127811164974.221.40.660.09
8UKMCau45Sclerosing inflammationLacrimalNo283898131311.13.643.10.680.35
9SGFCh54Chronic inflammation with prominent eosinophilsLacrimalNo19018409210.45NANANANA
10UKFCau12Chronic dacryoadenitisLacrimalNo207148741.75NANANANA
11UKFEuro47Chronic dacryoadenitisLacrimalNo722002802NANANANA
12UKMCau27Chronic dacryoadenitisOrbitalNo40511335NANANANA
13UKFCau67Chronic inflammationLacrimalTED1842221123.692.910.860.21
14SGFMalay54Necrotising granulomatous vasculitisLacrimalGPA100285028500.561.851.050.230.09
15SGFCh70Necrotising granulomatous vasculitisOrbitalGPA120173614300.475.645.120.860.2
16UKFCau35Chronic inflammationLacrimalTED40123750.5940.0057.054.750.530.83
17SGFCh64Sclerosing inflammationRectusTED50201040202NANANANA
18SGMCh43Necrotising granulomatous vasculitisOrbitalGPA102302529251.2NANANANA
19SGFCh59Sclerosing inflammationLacrimalSjogren’s disease1504210928730.39NANANANA
20SGFCh25Chronic dacryoadenitisLacrimalSjogren’s disease2055811428560.51NANANANA
21SGFCh86Chronic inflammationLacrimalPrimary biliary cirrhosis2424017417720.23NANANANA
22SGFInd54Chronic granulomatous inflammationLacrimalANA positive98153915400.38NANANANA
23SGFCh28Sclerosing inflammationLacrimalAI alopecia110393535321.11NANANANA
24UKFInd45Necrotising granulomatous vasculitisLacrimalGPA2671539957371.47NANANANA
25UKMCau82Small vessel vasculitisOrbitalSmall vessel vasculitis1742212313710.18NANANANA
26UKMInd37Small vessel vasculitisLacrimalSmall vessel vasculitis3374621514640.21NANANANA
  • AI, autoimmune; ANA, antinuclear antibody; Cau, Caucasian white; Ch, Chinese; Euro, European; F, female; GPA, granulomatosis with polyangiitis; IgG4-RD, IgG4-related disease; Ind, Indian; M, male; NA, Not applicable; OID, orbital inflammatory disorders; Oth, others; SG, Singapore; sIg, serum Ig; Syst, systemic; TED, thyroid eye disease; Tiss, tissue; UK, United Kingdom.