Change in visual acuity at 1 year from baseline by treatment stratified by starting visual acuity and adjusted for age, gender and year of starting therapy by multivariate modelling
| Starting visual acuity | Aflibercept compared with ranibizumab | |||
| n | Beta | 95% CI | p Value | |
| ≥70 ETDRS letters | 348 | 2.06 | −0.56 to 4.67 | 0.12 |
| 50 to 69 ETDRS letters | 822 | 3.99 | 1.61 to 6.37 | 0.001* |
| 30 to 49 ETDRS letters | 410 | 6.82 | 3.00 to 10.64 | 0.0005* |
| <30 ETDRS letters | 88 | 7.87 | −3.13 to 18.87 | 0.17 |
*p-value <0.05. ETDRS, Early Treatment Diabetic Retinopathy Study.