Table 2

Pharmacodynamic indices for topical administration of antimicrobial agents against Achromobacter xylosoxidans, Stenotrophomonas maltophilia and Pseudomonas aeruginosa

	Mean peak concentration (mcg/mL) (range)	Maximum concentration of topical dosing at site for A. xylosoxidans		Maximum concentration of topical dosing at site for S. maltophilia		Maximum concentration of topical dosing at site for P. aeruginosa
	Mean peak concentration (mcg/mL) (range)	Cmax/MIC₅₀	Cmax/MIC₉₀	Cmax/MIC₅₀	Cmax/MIC₉₀	Cmax/MIC₅₀	Cmax/MIC₉₀
Ciprofloxacin	5.2810	0.17	0.17	1.76	0.17	42.24	27.8
Moxifloxacin	30.58 (12.66–48.50)8 9	0.96	0.96	61.16	10.19	10.19	7.65
Tobramycin	0.14 (0.01–0.49)11–13 16	0.00055	0.00055	0.00055	0.00055	0.093	0.07
Trimethoprim/sulfamethoxazole	0.35 (0.22–0.47)13 15	1.84	0.92	1.40	0.70	0.03	0.01
Chloramphenicol	0.6014	0.0125	0.0023	0.025	0.00625	0.0023	0.0023

Published cornea peak concentration values8–10 were used for ciprofloxacin and moxifloxacin.
Published aqueous humour peak concentration values11–16 were used for tobramycin, trimethoprim/sulfamethoxazole and chloramphenicol.
Cmax, tissue peak concentration; MIC₅₀, minimum inhibitory concentrations for 50% of isolates; MIC₉₀, minimum inhibitory concentrations for 90% of isolates.