Table 2

Genotype and allele frequencies of PTPN2 and CD122 genes in ocular BD

Gene	SNPs	Stage	Genotype allele	BD		Controls		P value	P_cvalue	OR	95% CI
Gene	SNPs	Stage	Genotype allele	N	%	N	%	P value	P_cvalue	OR	95% CI
PTPN2	rs7234029	First	A	522	0.696	827	0.691	0.833	NS	1.022	0.838 to 1.245
			AA	166	0.443	296	0.495	0.112	NS	0.81	0.625 to 1.050
			AG	190	0.507	235	0.393	5.02×10⁻⁴	2.16×10⁻²	1.586	1.222 to 2.059
			GG	19	0.051	67	0.112	1.03×10⁻³	4.43×10⁻²	0.423	0.250 to 0.716
		Replication	A	746	0.702	2266	0.717	0.361	NS	0.931	0.800 to 1.085
			AA	234	0.441	806	0.51	0.006	NS	0.757	0.621 to 0.922
			AG	278	0.524	654	0.414	1.08×10⁻⁵	4.64×10⁻⁴	1.556	1.277 to 1.896
			GG	19	0.036	120	0.076	1.24×10⁻³	5.33×10⁻²	0.451	0.275 to 0.740
		Combined	A	1268	0.7	3093	0.71	0.419	NS	0.952	0.844 to 1.073
			AA	400	0.442	1102	0.506	1.10×10⁻³	4.73×10⁻²	0.772	0.661 to 0.902
			AG	468	0.517	889	0.408	3.33×10⁻⁸	1.43×10⁻⁶	1.549	1.326 to 1.810
			GG	38	0.042	187	0.086	1.94×10⁻⁵	8.34×10⁻⁴	0.466	0.326 to 0.667
	rs1893217	First	C	129	0.172	188	0.163	0.626	NS	1.063	0.831 to 1.359
			CC	6	0.016	16	0.028	0.236	NS	0.568	0.220 to 1.465
			CT	117	0.312	156	0.271	0.175	NS	1.218	0.916 to 1.621
			TT	252	0.672	403	0.701	0.347	NS	0.874	0.661 to 1.157
	rs657555	First	C	230	0.307	327	0.283	0.264	NS	1.121	0.917 to 1.371
			CC	27	0.072	51	0.088	0.372	NS	0.802	0.493 to 1.303
			CT	176	0.469	225	0.389	0.014	NS	1.388	1.067 to 1.805
			TT	172	0.459	302	0.522	0.054	NS	0.774	0.597 to 1.005
	rs2542151	First	G	136	0.181	197	0.165	0.352	NS	1.121	0.881 to 1.426
			GG	12	0.032	20	0.034	0.898	NS	0.954	0.461 to 1.974
			GT	112	0.299	157	0.263	0.226	NS	1.193	0.896 to 1.589
			TT	251	0.669	420	0.704	0.262	NS	0.853	0.646 to 1.126
	rs478582	First	C	125	0.167	216	0.187	0.273	NS	0.873	0.685 to 1.113
			CC	12	0.032	19	0.033	0.947	NS	0.975	0.468 to 2.033
			CT	101	0.27	178	0.308	0.21	NS	0.831	0.623 to 1.110
			TT	261	0.698	381	0.659	0.213	NS	1.194	0.903 to 1.580
CD122	rs228941	First	C	252	0.342	414	0.353	0.628	NS	0.953	0.785 to 1.157
			CC	40	0.109	64	0.109	0.98	NS	0.995	0.655 to 1.512
			CG	172	0.467	286	0.488	0.534	NS	0.921	0.709 to 1.195
			GG	156	0.424	236	0.403	0.517	NS	1.091	0.838 to 1.422
	rs743777	First	A	659	0.879	1082	0.905	0.069	NS	0.763	0.570 to 1.022
			AA	285	0.76	488	0.816	0.035	NS	0.714	0.521 to 0.978
			AG	89	0.237	106	0.177	0.023	NS	1.444	1.052 to 1.984
			GG	1	0.003	4	0.007	0.362	NS	0.397	0.044 to 3.566
	rs3218253	First	C	686	0.92	1100	0.932	0.298	NS	0.832	0.587 to 1.178
			CC	313	0.839	510	0.864	0.279	NS	0.818	0.569 to 1.177
			CT	60	0.161	80	0.136	0.279	NS	0.818	0.569 to 1.177
	rs743776	First	C	103	0.138	118	0.099	0.007	NS	1.468	1.107 to 1.946
			CC	5	0.013	3	0.005	0.158	NS	2.702	0.642 to 11.373
			CT	93	0.25	112	0.187	0.02	NS	1.446	1.059 to 1.976
			TT	274	0.737	483	0.808	0.009	NS	0.666	0.489 to 0.905
	rs2284033	First	A	480	0.647	743	0.623	0.296	NS	1.107	0.915 to 1.340
			AA	159	0.429	239	0.401	0.397	NS	1.12	0.861 to 1.457
			AG	162	0.437	265	0.445	0.808	NS	0.968	0.746 to 1.257
			GG	50	0.135	92	0.154	0.403	NS	0.853	0.588 to 1.237
	rs9622555	First	G	654	0.872	1054	0.887	0.313	NS	0.866	0.655 to 1.146
			GG	282	0.752	464	0.781	0.294	NS	0.85	0.627 to 1.152
			GT	90	0.24	126	0.212	0.31	NS	1.173	0.862 to 1.596
			TT	3	0.008	4	0.007	0.821	NS	1.19	0.265 to 5.345

BD, Behcet’s disease; NS, non-significant.