Table 1

The potential susceptibility loci identified in the ‘Immunochip’ study for Behcet’s disease

NumberSNPNearest gene(s)Chromosome Reported p values*
1rs17753641† IL12A 38.11E−10
2rs17810546† IL12A 31.01E−07
3rs601338 FUT2 196.51E−09
4rs1047781 FUT2 196.50E−04
5rs3783550 IL1A–IL1B 21.29E−08
6rs913678 CEBPB–PTPN1 201.10E−09
7rs7075773§ ADO-EGR2 101.69E−09
8rs1509966 ADO-EGR2 101.47E−06
9rs224127 ADO-EGR2 101.56E−06
10rs9316059 LACC1 131.16E−05
11rs10176241 THADA 23.05E−05
12rs79891766† LONRF2 23.60E−05
13rs116379815† RBM6 34.17E−07
14rs11248047 CPLX1 41.27E−07
15rs13190001† C5orf56 51.19E−05
16rs17705333 INHBA 71.82E−05
17rs9656588 IKZF1 75.28E−06
18rs10094579 RIPK2 86.03E−07
19rs2230801 RIPK2 89.60E−06
20rs911603 TNFSF8 91.17E−05
21rs28734985 IPMK-UBE2D1 104.10E−05
22rs1698386§ IPMK-UBE2D1 101.36E−05
23rs10896027 MAP3K11-RELA 112.58E−05
24rs58950470§ MAP3K11-RELA 116.25E−07
25rs4906762 ATP10A 153.81E−05
26rs3844576 SOCS1-TNP2 163.09E−06
27rs1793978 CKM-KLC3 192.70E−05
  • *The association of SNPs reported by the Immunochip study in Turkish patients.

  • †Some SNPs (six in total) were excluded since they were not polymorphic in Han Chinese (rs17753641, rs17810546, rs79891766, rs116379815, rs13190001 and rs1698386). The SNPrs2647935, with p<5×10−5, was selected as an alternative SNP in IL12A.

  • ‡The SNPs identified by meta-analysis.

  • §Imputed SNPs that with more significant association than the lead SNPs in loci and that is not in high linkage disequilibrium with lead SNPs in Chinese Han population (r2 <0.8, Han Chinese Beijing).

  • SNP, single nucleotide polymorphism.