Association analysis of HLA class I genes associated with CM-related SJS/TEN with SOC using combined data of patients with SJS/TEN
| HLA | Carrier frequency | Gene frequency | ||||||||
| Cases (%)(n=49) | Controls (%)(n=119) | P values | Pc-values* | OR (95% CI) | Cases (%)(n=98) | Controls (%)(n=318) | P values | Pc-values* | OR (95% CI) | |
| A*24:02 | 6.1(3/49) | 21.4(34/159) | 0.0173† | 0.2420† | 0.24(0.07 to 0.82) | 3.1(3/98) | 11.9(38/318) | 0.0105† | 0.1570 | 0.23(0.07 to 0.77) |
| A*33:03 | 40.8(20/49) | 23.3(37/159) | 0.0269† | 0.3760 | 2.27(1.15 to 4.48) | 24.5(24/98) | 11.9(38/318) | 0.0030† | 0.0520 | 2.39(1.35 to 4.23) |
| B*27:04 | 0(0/49) | 9.4(15/159) | 0.0244† | 0.4880 | 0.09(0.01 to 1.60) | 0(0/98) | 4.7(15/318) | 0.0270† | 0.5410 | 0.10(0.06 to 1.68) |
| B*40:01 | 4.1(2/49) | 18.9(30/159) | 0.0117† | 0.2330 | 0.18 (0.04 to 0.80) | 2(2/98) | 10.4(33/318) | 0.0064† | 0.1290 | 0.18(0.042 to 0.76) |
| B*44:03 | 34.7(17/49) | 6.9(11/159) | <0.0001† | 0.0001† | 7.15(3.06 to 16.7) | 19.4(19/98) | 3.5(11/318) | <0.0001† | <0.0001† | 6.71(3.07 to 14.70) |
| C*07:01 | 38.8(19/49) | 9.4(15/159) | <0.0001† | 0.0001† | 6.08(2.78 to 13.3) | 22.4(22/98) | 4.7(15/318) | <0.0001† | <0.0001† | 5.85(2.90 to 11.80) |
*The corrected p value indicates the p value after multiple comparisons (14 for carrier and 15 for gene of HLA-A, 20 for HLA-B and 16 for HLA-C).
†Analysis showed significant association between HLA and CM-related SJS/TEN with SOC at p<0.05.
CM, cold medicines; HLA, human leucocyte antigen; SJS/TEN, Stevens-Johnson syndrome/toxic epidermal necrolysis; SOC, severe ocular complications.