Table 3

Association of early age-related macular degeneration with SNPs

GeneSNP1 vs 0 copy of minor allele2 vs 0 copies of minor alleleAdditive per allele
OR*95% CIPOR*95% CIPOR*95% CIP
TLR3 rs37752911.010.86 to 1.200.8681.130.83 to 1.540.4251.040.92 to 1.160.520
LOC107986598 rs47117510.950.78 to 1.140.5580.910.69 to 1.200.5020.950.84 to 1.080.452
FRK rs19999300.830.66 to 1.050.1171.630.39 to 6.770.4980.880.69 to 1.120.285
ABCA1 rs18830250.960.79 to 1.170.6980.960.77 to 1.190.7260.980.88 to 1.090.699
LIPC rs104680170.970.82 to 1.140.6771.080.67 to 1.750.7440.990.85 to 1.150.913
CETP rs37642611.080.91 to 1.280.3651.100.90 to 1.330.3391.060.96 to 1.170.228
APOE rs4293580.930.77 to 1.120.4540.800.35 to 1.840.5940.930.77 to 1.100.380
APOE rs74120.970.74 to 1.270.8261.380.42 to 4.550.5941.000.79 to 1.270.994
CFD rs38269451.020.88 to 1.200.7581.100.87 to 1.390.3991.040.94 to 1.150.416
  • *Adjusted for age, sex and centre.

  • SNP, single nucleotide polymorphism.