Table 2

Association of neovascular age-related macular degeneration with SNPs

Gene	SNP	Major/minor alleles	1 vs 0 copy of minor allele		2 vs 0 copies of minor allele		Additive per minor allele
Gene	SNP	Major/minor alleles	OR*	95% CI	OR*	95% CI	OR*	95% CI	P	P†
Y402H	rs1061170	T/C	1.72	1.31 to 2.28	4.13	2.91 to 5.87	1.99	1.67 to 2.37	10⁻⁷	10⁻⁶
TLR3	rs3775291	C/T	1.18	0.92 to 1.51	0.88	0.51 to 1.53	1.06	0.87 to 1.30	0.545
C2	rs547154	C/A	0.62	0.47 to 0. 82	0. 64	0.29 to 1.43	0.67	0.53 to 0. 85	0.001	0.01
SKIV2L	rs438999	A/G	0.63	0.47 to 0.83	0.50	0.21 to 1.22	0.65	0.50 to 0.83	0.001	0.01
LOC107986598	rs4711751	T/C	0.35	0.27 to 0.46	0.65	0.45 to 0. 94	0.64	0.54 to 0. 77	10⁻⁴	10⁻³
FRK	rs1999930	C/T	0.93	0.64 to 1.34	5.94	1.17 to 30.10	1.05	0.74 to 1.49	0.777
ABCA1	rs1883025	C/T	0.81	0.61 to 1.07	0.58	0.41 to 0.83	0.77	0.65 to 0.92	0.003	0.04
ARMS2	rs10490923	G/A	0.49	0.35 to 0.67	0.85	0.33 to 2.17	0.57	0.43 to 0.75	10⁻³	0.04
ARMS2	rs10490924	G/T	1.86	1.37 to 2.51	8.73	6.11 to 12.48	2.94	2.45 to 3.52	10⁻¹⁰	10⁻⁹
HTRA1	rs2672598	T/C	1.53	1.01 to 2.32	5.42	3.58 to 8.21	2.67	2.19 to 3.25	10⁻⁹	10⁻⁸
LIPC	rs10468017	C/T	1.13	0.87 to 1.47	1.12	0.56 to 2.23	1.11	0.89 to 1.37	0.370
CETP	rs3764261	C/A	1.27	0.98 to 1.64	1.26	0.82 to 1.91	1.17	0.98 to 1.41	0.087
APOE	rs429358	T/C	0.82	0.60 to 1.14	NC‡		NC‡
APOE	rs7412	C/T	0.87	0.58 to 1.32	NC‡		NC‡
CFD	rs3826945	T/C	1.02	0.79 to 1.31	1.05	0.70 to 1.58	1.02	0.85 to 1.23	0.820

*Adjusted for age, sex and centre.
†Bonferroni-adjusted P value for 13 per-allele tests.
‡Not calculated, no cases with 2 copies of minor allele.
SNP, single nucleotide polymorphisms.