Association analysis of HLA class I genes associated with SJS/TEN with SOC using combined data of patients with SJS/TEN
| HLA | Carrier frequency | Gene frequency | ||||||||
| Cases (%) (n=71) | Controls (%) (n=119) | P values | Pc-values* | OR (95% CI) | Cases (%) (n=142) | Controls (%)(n=318) | P values | Pc-values* | OR (95% CI) | |
| A*33:03 | 43.7(31/71) | 23.3(37/159) | 0.0028† | 0.0333† | 2.56(1.41 to 4.64) | 24.6(35/142) | 11.9(38/318) | 0.0009† | 0.0104† | 2.41(1.45 to 4.02) |
| B*27:04 | 0(0/71) | 9.4(15/159) | 0.0066† | 0.1200 | 0.0652 (0.003 to 1.11) | 0(0/142) | 4.7(15/318) | 0.0076† | 0.1360 | 0.0687 (0.004 to 1.16) |
| B*44:03 | 31(22/71) | 6.9(11/159) | <0.0001† | 0.0001† | 6.04(2.73 to 13.3) | 16.9(24/142) | 3.5(11/318) | <0.0001† | <0.0001† | 5.68(2.70 to 12.0) |
| C*07:01 | 33.8(24/71) | 9.4(15/159) | <0.0001† | 0.0002† | 4.90(2.38 to 10.10) | 19(27/142) | 4.7(15/318) | <0.0001† | <0.0001† | 4.74(2.43 to 9.24) |
| C*12:02 | 1.4(1/71) | 11.9(19/159) | 0.0093† | 0.1400 | 0.105(0.01 to 0.80) | 0.7(1/142) | 6(19/318) | 0.0110† | 0.1650 | 0.112(0.01 to 0.84) |
*The corrected p value indicates the p value after multiple comparisons (12 for HLA-A, 18 for HLA-B and 15 for HLA-C).
†Analysis showed significant association between HLA and SJS/TEN with SOC at p<0.05.
HLA, human leucocyte antigen; SJS/TEN, Stevens-Johnson syndrome/toxic epidermal necrolysis; SOC, severe ocular complications.