Comparison of orbital MRI findings in the patients with MOG-ON and AQP4-ON
| MOG-ON | AQP4-ON | P value* | |
| Number of patients, (n) | 20 | 45 | |
| Orbital MRI lesion, n/total (%) | |||
| T2 lesion | 20/20, 100 | 45/45, 100 | |
| Post-enhancement | 16/20, 80 | 40/45, 88.9 | 0.570 |
| Radiological bilateral ON | 14/20, 70 | 30/45, 66.7 | 0.791 |
| Optic nerve head swelling | 16/20, 80 | 9/45, 20 | <0.001 |
| Retrobulbar | 16/20, 80 | 9/45, 20 | <0.001 |
| Canalicular | 6/20, 30 | 26/45, 57.8 | 0.039 |
| Intracranial | 3/20, 15 | 16/45, 35.6 | 0.093 |
| Chiasmal involvement | 3/20, 15 | 10/45, 22.2 | 0.737 |
| Optic tract involvement | 1/20, 5 | 3/45, 6.7 | >0.999 |
| Longitudinally extensive optic nerve lesion | 6/20, 30 | 26/45, 57.8 | 0.039 |
| Brain MRI lesion, n | 2/5 | 8/25 | >0.999 |
| Spinal MRI lesion, n | 0/8 | 17/32 | 0.020 |
Longitudinally extensive optic nerve lesion: the lesion involved more than 1/2 segments of the whole optic nerve.
*Pearson χ2 test.
AQP4-ON, aquaporin-4 antibody-associated ON; MOG-ON, myelin oligodendrocyte glycoprotein antibody-associated ON; ON, optic neuritis.