Association between ocular perfusion pressure profiles and primary open-angle glaucoma
| Model 1* | Model 2† | |||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Mean OPP (mm Hg) | ||||
| Per SD decrease (8.5 mm Hg) | 1.24 (1.04 to 1.48) | 0.015 | 1.07 (0.91 to 1.25) | 0.435 |
| Fourth quartile: >61 mm Hg | 1.00 (reference) | – | 1.00 (reference) | – |
| Third quartile: 55–61 mm Hg | 1.13 (0.76 to 1.67) | 0.548 | 0.98 (0.67 to 1.45) | 0.930 |
| Second quartile: 50– 55 mm Hg | 1.10 (0.73 to 1.64) | 0.658 | 0.94 (0.63 to 1.41) | 0.775 |
| First quartile: <50 mm Hg | 1.96 (1.30 to 2.98) | 0.002 | 1.34 (0.88 to 2.04) | 0.175 |
| Diastolic OPP (mm Hg) | ||||
| Per SD decrease (10.6 mm Hg) | 1.30 (1.08 to 1.56) | 0.005 | 1.06 (0.90 to 1.25) | 0.466 |
| Fourth quartile: >70 mm Hg | 1.00 (reference) | – | 1.00 (reference) | – |
| Third quartile: 62–70 mm Hg | 1.21 (0.81 to 1.81) | 0.360 | 1.08 (0.72 to 1.61) | 0.715 |
| Second quartile: 56–61 mm Hg | 1.41 (0.93 to 2.14) | 0.109 | 1.19 (0.78 to 1.81) | 0.421 |
| First quartile: <56 mm Hg | 1.78 (1.17 to 2.71) | 0.007 | 1.14 (0.74 to 1.76) | 0.562 |
| Systolic OPP (mm Hg) | ||||
| Per SD decrease (21.6 mm Hg) | 1.16 (0.97 to 1.38) | 0.105 | 1.06 (0.90 to 1.25) | 0.480 |
| Fourth quartile: >137 mm Hg | 1.77 (1.14 to 2.73) | 0.010 | 1.72 (1.13 to 2.61) | 0.011 |
| Third quartile: 123–137 mm Hg | 1.00 (reference) | – | 1.00 (reference) | – |
| Second quartile: 110–122 mm Hg | 1.77 (1.11 to 2.83) | 0.017 | 1.64 (1.03 to 2.63) | 0.038 |
| First quartile: <110 mm Hg | 2.23 (1.38 to 3.60) | 0.001 | 1.85 (1.16 to 2.95) | 0.009 |
*Model 1 adjusted for age, gender and ethnicity, diabetes, BMI, smoking status and antihypertensive medication.
†Model 2 adjusted for age, gender, ethnicity, diabetes, BMI, smoking status antihypertensive medication, IOP-lowering treatment and IOP.
BMI, body mass index; IOP, intraocular pressure; OPP, ocular perfusion pressure.