Table 1

Commercially available cyanoacrylate, fibrin and polyethylene glycol (PEG)-based surgical adhesives

Glue categoryGlue typeMoleculeCommercial name
CyanoacrylateSyntheticn-Butyl-2-cyanoacrylate1.Histoacryl (TissueSeal, Ann Arbor, Michigan, USA); manufactured by B. Braun, Melsungen, Germany)
2.Trufill (Cordis Neurovascular , Miami Lakes, Florida, USA)
3.Glubran2 (GEM, Viareggio, Italy)
4.Indermil (Covidien, Dublin, Ireland, acquired by Medtronic, Minneapolis, Minnesota, USA)
N-butyl-cyanoacrylate1.LiquiBand (Advanced Medical Solutions, Devon, England)
2.Nexacryl (Closure Medical, Raleigh, North Carolina, USA, acquired by Johnson & Johnson)
n-Hexyl cyanoacrylateIFAbond (Peters Surgical, 93000 Bobigny, France)
2-Octyl cyanoacrylateDermabond (Ethicon, Somerville, New Jersey, USA, acquired by Johnson & Johnson)
FibrinBiologicalTwo-part mixture: Part 1 includes human fibrinogen and aprotinin and factor XIII. Part 2 includes human thrombin and calcium chloride1.ARTISS (Baxter International, Deerfield, Illinois, USA)
2.Tisseel (Baxter International)
3.Tissucol (Baxter Hyland Immuno, Vienna, Austria)
4.Beriplast P (CSL Behring, King of Prussia, Pennsylvania, USA)
Two-part mixture: Part 1 includes fibrinogen–fibronectin and tranexamic acid. Part 2 includes thrombin and calcium chlorideQuixil (OMRIX Biopharmaceuticals, New York, New York, USA, acquired by Johnson & Johnson)
Two-part mixture. Part 1 includes human fibrinogen, arginine hydrochloride, glycine, sodium chloride, sodium citrate and calcium chloride. Part 2 includes human thrombin, calcium chloride, human albumin, mannitol and sodium acetateEvicel (distributed by Ethicon and manufactured by OMRIX Biopharmaceuticals; both companies acquired by Johnson & Johnson)
Human fibrinogen and thrombin coated on a backing layer of oxidised regenerated celluloseEvarrest (Ethicon, acquired by Johnson & Johnson)
Human fibrinogen, human thrombin, equine collagen, human albumin and so onTachosil (Baxter International)
Thrombin, cryoprecipitate, ethanol and calcium chlorideCryoSeal Fibrin Sealant (Thermogenesis Corp., Rancho Cordova, California, USA, acquired by Asahi Kasei Medical, Tokyo, Japan)
PEGSyntheticPEG ester powder crosslinked with trilysine amine solutionDuraSeal (Covidien acquired by Medtronic, Dublin, Ireland/Minneapolis, Minnesota, USA)
Mixture of PEG tetra-hydroxysuccinimide ester and PEG tetra-thiolCoSeal (Baxter International)
Human serum albumin crosslinked with PEG with functional succinate groupsProGel (Neomend, acquired by Bard, Irvine, California, USA)
Component 1: eosin-based primer
Component 2: PEG, polylactic acid, trimethylene carbonate and acrylic ester
Photo initiator: xenon light source
FocalSeal (Genzyme Corp., Cambridge,   Massachusetts, USA)
Powder PEG and liquid polyethylene amineOcuSeal (Beaver-Visitec International, Waltham, Massachusetts,  USA)
PEG with trilysine acetateReSure (Ocular Therapeutix, Bedford, Massachusetts, USA)
PEG with multiple additions—described in Sarfare et al 86 Medicus PEG (Medicus Bioscience, San Jose, California, USA)