Ocularfactors | Status | Univariable association | Multivariable association | Multivariable association |
Model 1* All glaucoma categories | Model 2† Glaucoma and other ocular pathologies | |||
HR (95%CI) | HR (95%CI) | HR (95%CI) | ||
POAG | No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Yes | 1.9 (1.23 to 2.94)‡ | 0.79 (0.45 to 1.38) | 0.82 (0.46 to 1.44) | |
PACG+PAC | No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Yes | 1.04 (0.5 to 2.2) | 1.38 (0.59 to 3.25) | 1.24 (0.5 to 2.9) | |
PACS | No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Yes | 1.55 (0.93 to 2.59) | 1.41 (0.8 to 2.5) | 1.33 (0.76 to 2.3) | |
Family history of glaucoma | No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Yes | 0.85 (0.12 to 6.02) | 0.78 (0.11 to 5.57) | 0.67 (0.1 to 4.8) | |
Unit increase in intraocular pressure | 1.01 (0.99 to 1.04) | 0.99 (0.96 to 1.02) | 0.99 (0.96 to 1.02) | |
Cup:disc ratio | Unit increase | 4.49 (2.64 to 7.64)‡ | 2.5 (1.3 to 5.1)‡ | 2.1 (1.03 to 4.2)‡ |
Pseudoexfoliation | No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Yes | 2.79 (2.0 to 3.89)‡ | 1.3 (0.92 to 1.84) | 1.22 (0.86 to 1.73) | |
Myopia | No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Yes | 1.78 (1.54 to 2.06)‡ | 1.12 (0.93 to 1.35) | 0.87 (0.71 to 1.07) | |
Hyperopia | No | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Yes | 0.85 (0.71 to 1.0) | 1.03 (0.83 to 1.27) | 1.01 (0.81 to 1.26) | |
Schoenfeldtest§ | 0.2 | 0.07 |
*Adjusted for age, gender, education level, diabetes, hypertension,body mass index (BMI)and smoking status.
†Adjusted for age, gender, education level, diabetes, hypertension, BMI, smoking status,visual impairment, pure nuclear cataract, pure cortical cataract, pureposterior subcapsular cataract, mixed cataract, history of cataract surgery andage-related macular degeneration.
‡Statistically significant (p<0.05).
§Goodness-of-fit test.
PAC, primary angle closure; PACG, primary angle closure glaucoma; PACS, primary angle closure suspect; POAG, primary open angle glaucoma; Ref, reference group.