Table 1

Genetic models of glaucoma

	IOP	Incidence	Onset and duration of RGC degeneration	Characteristics	References
DBA/2J	High	Dependent on colonies	8~15 months	Region specific RGC loss and systemic complications	24 25 34–38
Vav2/3 KO	High	Almost 75%	3~8 months	Buththalmos	40
P2Y₆ KO	High (POAG)	100%	6~13 months	Enhanced production of aqueous humour	41
Optineurin E50K knock-in	Normal	100%	3~12 months	Same as human genetic mutation	49
EAAC1 KO	Normal	100%	1~3 months	Early onset and short disease course Decrease in glutathione concentration in the retina and increased oxidative stress	21 23 54 62 69 86
GLAST KO	Normal	100%	KO: 3~5 weeks Heterozygous: 1~4 months		22 54 68 70 80

EAAC1, excitatory amino acid carrier 1; GLAST, glutamate/aspartate transporter; IOP, intraocular pressure; KO, knockout; POAG, primary open-angle glaucoma; RGC, retinal ganglion cell.