*†‡§¶**
Opacity scoreNuclear scoreCortical scorePosterior subcapsular score
Beta (95% CI)¶Beta (95% CI)¶Beta (95% CI)¶
Participants (n)431843364334
Participants genotype134 GA/AA, 4184 GG134 GA/AA, 4202 GG134 GA/AA, 4200 GG
AA and GA versus GG0.007 (−0.159 to 0.173)0.187 (0.005 to 0.369)0.103 (−0.080 to 0.286)
P effect0.9320.0450.264
P difference by centre0.4550.7980.220
  • Any cataract type (pure or mixed) defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2.

  • Comparator group (controls) without cataract or operated cataract (ie <4 for nuclear opacities and <3 for cortical opacities and <2 for posterior subcapsular cataract, no dense opacities and no aphakia/pseudophakia); n=1462, 40 GA/AA and 1422 GG.

  • OR and 95% CI calculated from logistic regression adjusted for age, sex, study centre.

  • Pure cataract type defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2, and no other type of opacity.

  • Beta coefficient (Beta) and 95% CI from regression analysis adjusted for age, sex, study center.

  • Standardised scores of Lens Opacity Classification System III grade: nuclear opacity score in the worse eye graded in 0.1 units from 0.5 to 6.9; cortical opacity score in the worse eye graded in 0.1 units from 0 to 5.9; posterior capsular opacity score in the worse eye graded in 0.1 units from 0 to 5.9.