*†‡§¶**
Opacity scores¶Nuclear scoreCortical scorePosterior subcapsular score
Beta (95% CI)**Beta (95% CI)**Beta (95% CI)**
Participants (n)429243104308
Per allele association0.030 (−0.006 to 0.065)−0.018 (−0.054 to 0.019)0.021 (−0.022 to 0.063)
P effect0.1030.3390.338
P difference by centre0.6830.1810.761
  • Any cataract type (pure or mixed) defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2.

  • Comparator group (controls) without cataract or operated cataract (ie <4 for nuclear opacities and <3 for cortical opacities and <2 for posterior subcapsular cataract, no dense opacities and no aphakia/pseudophakia); n=1462.

  • OR and 95% CI calculated from logistic regression adjusted for age, sex, study centre.

  • Pure cataract type defined as Lens Opacity Classification System III grade: nuclear opacities ≥4 cortical opacities ≥3, posterior subcapsular opacities ≥2 and no other type of opacity.

  • Standardised scores of Lens Opacity Classification System III grade: nuclear opacity score in the worse eye graded in 0.1 units from 0.5 to 6.9; cortical opacity score in the worse eye graded in 0.1 units from 0 to 5.9; posterior capsular opacity score in the worse eye graded in 0.1 units from 0 to 5.9.

  • Beta coefficient (Beta) and 95% CI from regression analysis adjusted for age, sex, study centre.