Opacity scores¶ | Nuclear score | Cortical score | Posterior subcapsular score |

Beta (95% CI)** | Beta (95% CI)** | Beta (95% CI)** | |

Participants (n) | 4292 | 4310 | 4308 |

Per allele association | 0.030 (−0.006 to 0.065) | −0.018 (−0.054 to 0.019) | 0.021 (−0.022 to 0.063) |

P effect | 0.103 | 0.339 | 0.338 |

P difference by centre | 0.683 | 0.181 | 0.761 |

Any cataract type (pure or mixed) defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2.

Comparator group (controls) without cataract or operated cataract (ie <4 for nuclear opacities and <3 for cortical opacities and <2 for posterior subcapsular cataract, no dense opacities and no aphakia/pseudophakia); n=1462.

OR and 95% CI calculated from logistic regression adjusted for age, sex, study centre.

Pure cataract type defined as Lens Opacity Classification System III grade: nuclear opacities ≥4 cortical opacities ≥3, posterior subcapsular opacities ≥2 and no other type of opacity.

Standardised scores of Lens Opacity Classification System III grade: nuclear opacity score in the worse eye graded in 0.1 units from 0.5 to 6.9; cortical opacity score in the worse eye graded in 0.1 units from 0 to 5.9; posterior capsular opacity score in the worse eye graded in 0.1 units from 0 to 5.9.

Beta coefficient (Beta) and 95% CI from regression analysis adjusted for age, sex, study centre.