Table 2

Existing drugs with possibility of drug repositioning for glaucoma

	Existing indications	Characteristics	Side effects	Usage models	References
Candesartan	Hypertension Heart failure	Angiotensin II receptor antagonist	Birth defects Low blood pressure High blood potassium	EAAC1 KO mouse	21
Valproic acid	Epilepsy Migraines Bipolar disorder	Histone deacetylase inhibitor	Birth defects Liver dysfunction Thrombocytopaenia	GLAST KO mouse NMDA injection	22 28
Geranylgeranyl acetone	Gastric ulcers	Antioxidant Hsp70 inducer	Liver dysfunction Jaundice	GLAST KO mouse	70
Edaravone	Acute stroke ALS	Free radical scavenger	Acute renal failure Liver dysfunction	EAAC1 KO mouse Optic nerve injury	23 77
Nicotinamide	Pellagra High cholesterol Skin diseases	Vitamin B3 antioxidant and antipruritic	Skin flushing Low blood pressure Hyperglycaemia Liver dysfunction	DBA/2J mouse	24
Amlexanox	Aphthous ulcers Bronchial asthma Allergic rhinitis	Antiallergic immunomodulator and TBK1 inhibitor	Skin rash Headache Nausea Diarrhoea Liver dysfunction	Optineurin E50K knock-in mouse	49

ALS, amyotrophic lateral sclerosis; EAAC1, excitatory amino acid carrier 1; GLAST, glutamate/aspartate transporter; Hsp70, heat shock protein 70; KO, knockout; NMDA, N-methyl-D-aspartate; TBK1, TANK-binding kinase 1.