IOP | Incidence | Onset and duration of RGC degeneration | Characteristics | References | |
DBA/2J | High | Dependent on colonies | 8~15 months | Region specific RGC loss and systemic complications | 24 25 34–38 |
Vav2/3 KO | High | Almost 75% | 3~8 months | Buththalmos | 40 |
P2Y6 KO | High (POAG) | 100% | 6~13 months | Enhanced production of aqueous humour | 41 |
Optineurin E50K knock-in | Normal | 100% | 3~12 months | Same as human genetic mutation | 49 |
EAAC1 KO | Normal | 100% | 1~3 months | Early onset and short disease course Decrease in glutathione concentration in the retina and increased oxidative stress | 21 23 54 62 69 86 |
GLAST KO | Normal | 100% | KO: 3~5 weeks Heterozygous: 1~4 months | 22 54 68 70 80 |
EAAC1, excitatory amino acid carrier 1; GLAST, glutamate/aspartate transporter; IOP, intraocular pressure; KO, knockout; POAG, primary open-angle glaucoma; RGC, retinal ganglion cell.