Summary of the most significant results in univariate analysis of the association of ocular and systemic factors with the number of anti-VEGF injections required over 2 years of Observe-and-Plan, an interval-based variable-dosing regimen for neovascular age-related macular degeneration
Factors | n | Mean number of anti-VEGF injections Mean±SD | P values |
Overall | 205 | 14.1±5.9 | |
Quartiles | 205 | 10/14/18 | |
Ocular baseline characteristics | |||
RPE detachment baseline | |||
Present ≥200 µm height | 57 | 15.4±0.8 | 0.054 |
Absent or <200 µm height | 148 | 13.6±0.5 | |
Per 10 µm thickness increase | 205 | 0.09±0.00 (r=0.27) | 0.0001* |
CRT baseline | |||
Per 10 µm thickness (corrected for study/SD-OCT machine) | 205 | 0.10±0.003 (r=0.22) | 0.002* (0.02*) |
Subretinal fluid | |||
Present | 18 | 14.5±0.46 | 0.17 |
Absent | 46 | 13.1±0.86 | |
Missing data | 1 | ||
Per 10 µm thickness increase | 204 | 0.07±0.004 (r=0.12) | 0.10 |
Depigmentation | |||
Present | 109 | 13.3±0.56 | 0.06 |
Absent | 89 | 14.9±0.62 | |
Ocular follow-up characteristics | |||
Study | |||
Aflibercept/OCT Spectralis /team 2 | 100 | 15.2±0.58 | 0.01* |
Ranibizumab/OCT Cirrus/team 1 | 105 | 13.1±0.56 | |
Type of fluid at month 3 | |||
Subretinal+intraretinal fluid | 25 | 19.5±1.04 | |
Subretinal fluid only | 25 | 16.9±1.04 | |
Intraretinal fluid only | 91 | 14.1±0.55 | <0.0001* |
No subretinal or intraretinal fluid | 64 | 11.0±0.65 | |
Subretinal fluid at month 3 | |||
Present | 50 | 18.2±0.76 | <0.0001* |
Absent | 155 | 12.8±0.43 | |
Intraretinal fluid at month 3 | |||
Present | 116 | 15.3±0.53 | |
Absent | 89 | 12.6±0.61 | 0.001* |
RPE detachment at month 3 | |||
Per 10 µm thickness | 205 | 0.12±0.003 (r=0.27) | <0.0001* |
CRT at month 3 | |||
Per 10 µm thickness (corrected for study/OCT machine) | 205 | 0.36±0.006 (r=0.38) | <0.0001* (<0.0001*) |
Systemic characteristics | |||
BMI (kg/m2) | |||
Per unit | 189 | −0.13±0.09 (r=−0.11) | 0.12 |
Antidepressant medication | |||
Yes | 19 | 13.8±0.43 | |
No | 184 | 16.0±1.33 | 0.12 |
Missing data | 2 |
*P<0.05.
RPE=retinal pigment epithelium; CRT=central retinal thickness; BMI=body mass index.
Anti-VEGF, antivascular endothelial growth factor; BMI, body mass index; CRT, central retinal thickness; RPE, retinal pigment epithelium; SD-OCT, spectral domain optical coherence tomography.