Table 3

Summary of determinants of macular thickness parameters in SEED and previous population-based studies

StudiesMacular thickness parametersOCTAgeFemaleSEALBMIDM/FGSmoking
SEEDOMTSDOCT (Cirrus HD-OCT, Carl Zeiss Meditec)NilNil
CSMTNilNil
UKBBOMTSDOCT (Topcon 3D OCT-1000 Mark II; Topcon GB, Newberry, Berkshire, UK)NANA
CSMT↓/↑*NANA
HDESCSMTTDOCT (Stratus OCT, Carl Zeiss Meditec)NilNilNA
BDESCSMTSDOCT (Topcon 3D-OCT 1000-Mark II)NilNANANA
  • ↓denotes significant negative association with respective macular thickness parameter; ↑ denotes significant positive association.

  • *Negative correlation for age group of 60–69 years, and positive correlation for age group of 40–59 years.

  • AL, axial length; BMI, body mass index; BDES, Beaver Dam Eye Study; CSMT, central subfield macular thickness; DM, diabetes mellitus; FG, fasting glucose; HDES, Handan Eye Study; NA, denotes uninvestigated factor in the studdy, OCT, optical coherence tomography; OMT, overall average macular thickness; SDOCT, spectral-domain OCT; TDOCT, time-domain OCT; SE, spherical equivalent; SEED, Singapore Epidemiology of Eye Diseases; UKBB, United Kingdom Biobank Study.