Table 1

Baseline characteristics of the IVB and IVB/IVF groups

ParameterTotalGroupP values
IVBIVB/IVF
Age (years)
 Mean±SD57.9±8.458.9±8.857.1±8.20.568*
 Median (range)57.5(44–75)60(44–75)57(44–75)
Sex
 Male22(52.4%)12(60.0%)10(45.5%)0.346†
 Female20(47.6%)8(40.0%)12(54.5%)
Stage of DR
 Moderate NPDR20(47.7%)13(66.7%)7(31.8%)0.121‡
 Severe NPDR12(28.5%)3(16.7%)9(40.9%)
 Regressed PDR10(23.8%)4(16.7%)6(27.3%)
Macular ischaemia
 No27(63.3%)15(75.0%)12(55.0%)0.442§
 Yes15(36.7%)5(25.0%)10(45.0%)
Previous IVB injections (%)
 No14(33.3%)6(30%)8(36.4%)0.662†
 Yes28(66.7%)14(70%)14(63.6%)
Previous IVB injections (n)
 Mean±SD2.2±2.12.6±2.52±1.90.447‡
 Median (range)2(0–8)2(0–8)1(0–6)
Previous MPC sessions
 Mean±SD0.6±1.30.5±1.40.7±1.20.523‡
 Median (range)0(0–5)0(0–5)0(0–4)
Previous IVT injections (%)
 No38(90.5%)16(77.8%)22(100.0%)0.142§
 Yes4(9.5%)4(22.2%)0(0.0%)
FBS (mg/dL)
 Mean±SD184.4±75.3181.3±69.6186.7±81.50.854*
 Median (range)167(82–359)163(104–359)167(82–359)
Creatinine (mg/dL)
 Mean±SD1.09±0.271.1±0.161.08±0.330.831*
 Median (range)1(0.6–1.83)1.05(0.88–1.4)1(0.6–1.83)
 HbA1c
 Mean±SD7.9±1.47.4±18.2±1.50.188*
 Median (range)7.9(5.8–10.3)7.5(5.8–8.8)8.7(6.3–10.3)
 BUN (mg/dL)
 Mean±SD22.69±5.4125.93±3.5820.25±5.620.190*
 Median (range)23(13–29)26.8(22–29)21(13–26)
  • *Based on t-test.

  • †Based on χ2 test.

  • ‡Based on Mann-Whitney test.

  • §Based on Fisher’s exact test.

  • BUN, blood urea nitrogen; DR, diabetic retinopathy; FBS, fasting blood sugar; IVB, intravitreal injection of bevacizumab;IVB/IVF, intravitreal injection of both bevacizumab and fasudil; IVT, intravitreal injection of triamcinolone acetonide; MPC, macular photocoagulation; NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.