General demographics of control and patients with OAG
| All | Male | Female | ||||||||||||||||
| Control | OAG | Control vs OAG | Control | OAG | Control vs OAG | Control | OAG | Control vs OAG | ||||||||||
| All | Mild | Moderate | Severe | P values | All | Mild | Moderate | Severe | P values | All | Mild | Moderate | Severe | P values | ||||
| Number | 37 | 123 | 43 | 38 | 42 | – | 18 | 61 | 18 | 21 | 22 | – | 19 | 62 | 25 | 17 | 20 | – |
| NTG:POAG | – | 89:34 | 35:8 | 26:12 | 28:14 | – | – | 42:19 | 14:4 | 13:8 | 15:7 | – | – | 47:15 | 21:4 | 13:4 | 13:7 | – |
| Age (years) | 58.1±11.0 | 61.3±12.5 | 60.1±12.9 | 61.2±14.1 | 62.7±10.6 | 0.18 | 58.8±13.6 | 61.9±12.8 | 59.7±14.1 | 62.5±12.7 | 63.1±12.3 | 0.51 | 57.3±8.3 | 60.8±12.3 | 60.4±12.4 | 59.5±15.8 | 62.4±8.6 | 0.21 |
| Sex (male:female) | 18:19 | 61:62 | 18:25 | 21:17 | 22:20 | 0.92* | – | – | – | – | – | – | – | – | – | – | – | – |
| SBP (mm Hg) | 123.32±14.82 | 125.19±17.69 | 124.85±17.74 | 128.26±18.48 | 123.10±17.10 | 1.00 | 125.56±13.30 | 127.55±17.56 | 128.17±16.05 | 129.94±18.19 | 125.32±18.78 | 0.89 | 121.21±16.21 | 122.74±17.64 | 122.13±18.94 | 126.47±19.25 | 120.24±14.69 | 0.96 |
| DBP (mm Hg) | 74.76±12.16 | 76.55±12.94 | 77.05±12.07 | 78.23±12.83 | 74.69±13.96 | 0.42 | 79.22±11.27 | 79.36±13.39 | 81.89±12.71 | 81.88±9.65 | 75.45±15.69 | 0.9 | 70.53±11.69 | 73.63±11.89 | 73.09±10.16 | 74.33±14.88 | 73.71±11.76 | 0.25 |
| Hypertension (%) | 11 (29.73) | 40 (32.52) | 16 (37.21) | 12 (31.58) | 12 (28.57) | 0.75* | 7 (38.89) | 17 (27.87) | 7 (38.89) | 6 (28.57) | 4 (18.18) | 0.38* | 4 (21.05) | 23 (37.10) | 9 (36.00) | 6 (35.29) | 8 (40.00) | 0.18* |
| Diabetes (%) | 2 (5.41) | 13 (10.57) | 5 (11.63) | 4 (10.53) | 4 (9.52) | 0.31* | 1 (5.56) | 8 (13.11) | 4 (22.22) | 1 (4.76) | 3 (13.64) | 0.34* | 1 (5.26) | 5 (8.06) | 1 (4.00) | 3 (17.65) | 1 (5.00) | 0.66* |
| Hyperlipidaemia (%) | 4 (10.81) | 20 (16.26) | 6 (13.95) | 8 (21.05) | 6 (14.29) | 0.39* | 2 (11.11) | 10 (16.39) | 3 (16.67) | 4 (19.05) | 3 (13.64) | 0.57* | 2 (10.53) | 10 (16.13) | 3 (12.00) | 4 (23.53) | 3 (15.00) | 0.52* |
| Current smoker (%) | 6 (16.22) | 11 (8.94) | 3 (6.98) | 4 (10.53) | 4 (9.52) | 0.23* | 5 (27.78) | 9 (14.75) | 2 (11.11) | 3 (14.29) | 4 (18.18) | 0.22* | 1 (5.26) | 2 (3.23) | 1 (4.00) | 1 (5.88) | 0 (0.00) | 0.69* |
| MtDNA/nDNA | 220.55±70.23 | 257.76±68.21 | 252.28±66.28 | 266.03±68.87 | 255.88±70.47 | <0.01 | 218.15±86.33 | 255.15±69.39 | 242.82±73.74 | 283.61±79.13 | 238.06±46.30 | 0.01 | 222.83±53.05 | 260.33±67.50 | 259.10±61.01 | 244.31±47.27 | 275.48±87.02 | 0.01 |
| AL (mm) | 24.44±1.00 | 24.60±1.19 | 24.53±1.25 | 24.75±1.15 | 24.53±1.18 | 0.39 | 24.40±1.03 | 24.74±1.12 | 24.46±1.17 | 24.80±1.12 | 24.93±1.07 | 0.21 | 24.48±1.01 | 24.46±1.25 | 24.58±1.33 | 24.69±1.23 | 24.10±1.16 | 0.96 |
| IOP (mm Hg) | 13.92±2.36 | 14.05±3.59 | 13.74±3.42 | 14.51±3.46 | 13.95±3.91 | 0.69 | 13.78±2.92 | 14.48±4.11 | 14.61±3.84 | 14.38±4.06 | 14.45±4.53 | 0.71 | 14.05±1.75 | 13.62±2.96 | 13.08±2.98 | 14.69±2.60 | 13.40±3.12 | 0.25 |
| CpRNFLT (mm) | 106.83±8.07 | 81.93±13.13 | 88.15±13.10 | 82.35±12.50 | 75.18±10.43 | <0.01 | 106.14±5.51 | 80.06±13.86 | 85.52±16.38 | 81.85±12.78 | 73.87±10.36 | <0.01 | 107.47±10.04 | 83.77±12.21 | 90.03±10.08 | 82.96±12.51 | 76.61±10.57 | <0.01 |
| MD (dB) | – | −9.02±5.06 | −3.05±1.73 | −9.08±2.03 | −14.73±1.74 | – | – | −9.37±4.90 | −3.45±2.00 | −8.89±1.74 | −14.67±1.68 | – | – | −8.68±5.23 | −3.38±1.55 | −9.31±2.38 | −14.78±1.84 | – |
Unmarked p value: Mann-Whitney U test.
*Fisher’s exact test.
AL, axial length; cpRNFLT, circumpapillary retinal nerve fibre layer thickness; DBP, diastolic blood pressure; IOP, intraocular pressure; MD, mean deviation; mtDNA/nDNA, mitochondrial/nuclear DNA; NTG, normal-tension glaucoma; OAG, open-angle glaucoma; POAG, primary open-angle glaucoma; SBP, systolic blood pressure.