Table 1

Association of rs33972313 with types of cataract (1) mixed cataracts, (2) pure cataracts and (3) lens opacity scores in the two centre India age-related Eye Disease population study (INDEYE)

Mixed cataracts*†Any nuclearAny corticalAny posterior subcapsular
OR (95% CI)‡OR (95% CI)‡OR (95% CI)‡
Cases (n)22954941026
Case genotype (n)73 GA/AA, 2222 GG20 GA/AA, 474 GG37 GA/AA, 989 GG
AA and GA versus GG1.27 (0.83 to 1.95)2.16 (1.34 to 3.49)1.68 (1.06 to 2.65)
P effect0.2790.0020.03
P difference by centre0.7890.5690.676
Pure cataracts§†Pure nuclearPure corticalPure posterior subcapsular
OR (95% CI)‡OR (95% CI)‡OR (95% CI)‡
Cases (n)1429192222
Case genotype (n)41 GA/AA, 1388 GG9 GA/AA, 183 GG6 GA/AA, 216 GG
AA and GA versus GG1.11 (0.69 to 1.80)2.29 (1.12 to 4.65)1.19, (0.56 to 2.52)
P effect0.6710.0230.653
P difference by centre0.6720.9950.712
Opacity scoreNuclear scoreCortical scorePosterior subcapsular score
Beta (95% CI)¶Beta (95% CI)¶Beta (95% CI)¶
Participants (n)431843364334
Participants genotype134 GA/AA, 4184 GG134 GA/AA, 4202 GG134 GA/AA, 4200 GG
AA and GA versus GG0.007 (−0.159 to 0.173)0.187 (0.005 to 0.369)0.103 (−0.080 to 0.286)
P effect0.9320.0450.264
P difference by centre0.4550.7980.220
  • Any cataract type (pure or mixed) defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2.

  • Comparator group (controls) without cataract or operated cataract (ie <4 for nuclear opacities and <3 for cortical opacities and <2 for posterior subcapsular cataract, no dense opacities and no aphakia/pseudophakia); n=1462, 40 GA/AA and 1422 GG.

  • OR and 95% CI calculated from logistic regression adjusted for age, sex, study centre.

  • Pure cataract type defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2, and no other type of opacity.

  • Beta coefficient (Beta) and 95% CI from regression analysis adjusted for age, sex, study center.

  • Standardised scores of Lens Opacity Classification System III grade: nuclear opacity score in the worse eye graded in 0.1 units from 0.5 to 6.9; cortical opacity score in the worse eye graded in 0.1 units from 0 to 5.9; posterior capsular opacity score in the worse eye graded in 0.1 units from 0 to 5.9.