Table 2

Association of rs6596473 with types of cataract (1) mixed cataracts, (2) pure cataracts and (3) lens opacity scores in the two centre India age-related Eye Disease population study (INDEYE)

Mixed cataracts*†Any nuclearAny corticalAny posterior subcapsular
OR (95% CI)‡OR (95% CI)‡OR (95% CI)‡
Cases (n)22884911026
Additive association1.05 (0.97 to 1.15)1.02 (0.86 to 1.22)1.05 (0.93 to 1.19)
P effect0.2200.7890.406
P difference by centre0.8260.7820.918
Pure cataracts§†Pure nuclearPure corticalPure posterior subcapsular
OR (95% CI)‡OR (95% CI)‡OR (95% CI)‡
Cases (n)1421187218
Additive association1.05 (0.95 to 1.17)0.97 (0.76 to 1.24)0.99 (0.78 to 1.27)
P effect0.3040.8250.966
P difference by centre0.9040.5640.821
Opacity scores¶Nuclear scoreCortical scorePosterior subcapsular score
Beta (95% CI)**Beta (95% CI)**Beta (95% CI)**
Participants (n)429243104308
Per allele association0.030 (−0.006 to 0.065)−0.018 (−0.054 to 0.019)0.021 (−0.022 to 0.063)
P effect0.1030.3390.338
P difference by centre0.6830.1810.761
  • Any cataract type (pure or mixed) defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2.

  • Comparator group (controls) without cataract or operated cataract (ie <4 for nuclear opacities and <3 for cortical opacities and <2 for posterior subcapsular cataract, no dense opacities and no aphakia/pseudophakia); n=1462.

  • OR and 95% CI calculated from logistic regression adjusted for age, sex, study centre.

  • Pure cataract type defined as Lens Opacity Classification System III grade: nuclear opacities ≥4 cortical opacities ≥3, posterior subcapsular opacities ≥2 and no other type of opacity.

  • Standardised scores of Lens Opacity Classification System III grade: nuclear opacity score in the worse eye graded in 0.1 units from 0.5 to 6.9; cortical opacity score in the worse eye graded in 0.1 units from 0 to 5.9; posterior capsular opacity score in the worse eye graded in 0.1 units from 0 to 5.9.

  • Beta coefficient (Beta) and 95% CI from regression analysis adjusted for age, sex, study centre.