Table 2

Genotype frequencies for 7 TMCO1 SNPs and association with POAG

SNPGenotypes
alleles
Cases (%)Controls (%)Hardy-
Weinberg
Age and sex
adjusted
OR (95% CI)
P value
rs11430311InsT/insT925 (60.3)938 (59.8)0.99Reference0.76
InsT/WT533 (34.8)546 (34.8)0.99 (0.84 to 1.17)
WT/WT75 (4.9)84 (5.4)0.88 (0.62 to 1.25)
InsT2383 (77.7)2422 (77.2)Reference0.60
WT683 (22.3)714 (22.8)0.97 (0.85 to 1.10)
rs4657473CC1251 (81.4)1272 (81.0)0.02Reference<0.001
CT275 (17.9)265 (16.9)1.05 (0.86 to 1.29)
TT10 (0.7)33 (2.1)0.20 (0.09 to 0.42)
C2777 (90.4)2809 (89.5)Reference0.08
T295 (9.6)331 (10.5)0.85 (0.71 to 1.02)
rs4657474GG926 (60.3)941 (59.9)0.76Reference0.81
GA537 (35.0)549 (35.0)1.00 (0.85 to 1.18)
AA73 (4.8)80 (5.1)0.89 (0.62 to 1.27)
G2389 (77.8)2431 (77.4)Reference0.70
A683 (22.2)709 (22.6)0.97 (0.86 to 1.11)
rs4657475CC926 (60.3)941 (60.0)0.65Reference0.81
CT538 (35.0)549 (35.0)1.00 (0.85 to 1.18)
TT72 (4.7)79 (5.0)0.89 (0.62 to 1.28)
C2390 (77.8)2431 (77.5)Reference0.72
T682 (22.2)707 (22.5)0.98 (0.86 to 1.11)
rs116461237GG1492 (97.2)1527 (97.3)0.60Reference0.68
GA43 (2.8)41 (2.6)1.03 (0.64 to 1.64)
AA0 (0.0)1 (0.1)N/A
G3027 (98.6)3095 (98.6)Reference0.98
A43 (1.4)43 (1.4)0.99 (0.63 to 1.57)
rs61058666GG1336 (87.0)1355 (86.4)0.47Reference0.95
GC192 (12.5)209 (13.3)1.01 (0.81 to 1.27)
CC7 (0.5)5 (0.3)1.21 (0.34 to 4.27)
G2864 (93.3)2919 (93.0)Reference0.84
C206 (6.7)219 (7.0)1.02 (0.82 to 1.27)
rs4656461AA925 (60.3)940 (59.9)0.65Reference0.81
AG538 (35.0)549 (35.0)1.01 (0.86 to 1.18)
GG72 (4.7)79 (5.0)0.89 (0.62 to 1.28)
A2388 (77.8)2429 (77.5)Reference0.75
G682 (22.2)707 (22.5)0.78 (0.86 to 1.11)
  • *P values for any difference between three genotypes, and linear difference by number of alleles, respectively.

  • POAG, primary open-angle glaucoma; SNP, single nucleotide polymorphism.