Table 1

Demographic and clinical characteristics of patients included in the study

rhNGF 20 µg/mLrhNGF 4 µg/mLP value
Gender—N (%)
 Female16 (80%)17 (85%)NSS
 Male4 (20%)3 (15%)
 Years (mean±SD)48.4±12.055.9±14.8NSS
 Caucasian—N (%)20 (100%)20 (100%)NSS
Body weight
 kg (mean±SD)70.7±8.773.2±18.3NSS
 cm (mean±SD)167.7±8.2165.1±7.3NSS
Vital signs
 Blood pressure
  Systolic/Diastolic blood pressure mm Hg (mean±SD)126.2±15.1/78.5±8.5123.1±18/75.7±10NSS
  Pulse rate beats/min (mean±SD)71.5±7.476.1±11NSS
Dry eye severity (DWES classification-N)
 Very severe12
Frequency of DED symptoms (SANDE scale)
Severity of DED symptoms (SANDE scale)
OSDI score
Frequency of AT use
 Number of daily administration (mean±SD)2.9±3.93.3±1.9NSS
 ETDRS number of letters (mean±SD)85.5±5.574.6±21.9NSS
Ocular surface staining5.2±25.9±2.7NSS
 (NEI scale) total score cornea (mean±SD) total score8.1±3.56.8±2.7NSS
 conjunctiva (mean±SD) total score (mean±SD)13.3±4.912.6±5.1NSS
Cornea sensitivity
 (Cochet-Bonnet esthesiometer) mm (mean±SD)5.6±0.95.4±1.2NSS
Schirmer test type I
 mm/5 min (mean±SD)4.1±3.35.2±3.7NSS
Break-up time
 s (mean±SD)3.4±23.0±2.4NSS
Tear osmolarity (Tear Lab)
 mOsm/L (mean±SD)313.6±13.7313.6±16.1NSS
  • AT, artificial tears; BCVA, best-corrected visual acuity; DED, dry eye disease; NEI, National Eye Institute; NSS, not statistically significant; OSDI, Ocular Surface Disease Index.

  • DEWS, Dry Eye Workshop

  • DEWS, Dry Eye Workshop.