Table 1

Univariate and multivariate analysis results show risk factors for IgG4-related ophthalmic disease relapse after systemic corticosteroid treatment

FactorUnivariate analysis
(Log-rank test)
Multivariate analysis A
(Cox hazard model)
Multivariate analysis B
(Cox hazard model)
P valueHR (95% CI)P valueHR (95% CI)P value
Age (>60 years)0.6
Sex (male)0.04*1.4 (0.6 to 3.3)0.4
Anatomic locations
 Laterality (bilateral)0.5
 Lacrimal glands0.7
 EOMs and CN V0.0002*2.7 (1.1 to 6.7)0.03*2.5 (1.0 to 6.3)0.04*
 Other ocular adnexal lesions0.3
 Systemic involvement0.5
 IgG4:IgG ratio (>0.6)0.8
Serological data
 Serum IgG4 level (>900 mg/dL)0.3
 Serum IgG4 level (>400 mg/dL)0.01*1.4 (0.6 to 3.6)0.51.4 (0.5 to 3.5)0.5
 Blood eosinophilia (yes)0.02*
 Rheumatoid factor (positive)0.04*1.1 (0.5 to 2.7)0.8
  • *Statistically significant.

  • †Complications of IgG4-related ophthalmic disease include asthma, rhinitis refractory to conventional medications, atopic dermatitis and hyposmia.

  • CN V, trigeminal nerve; EOMs, extraocular muscles; IgG4, immunoglobulin G4.