Genotype and allele frequencies of PRM1, JAZF1, IRF5, MEFV, PSMA3 and PTPN2 polymorphisms in patients with JIA-U versus healthy controls
| Genotype/Allele | JIA-U | Control | P | Pc | OR (95% CI） | ||
| N | % | N | % | ||||
| PRM1/rs11074967 | |||||||
| CC | 93 | 0.69 | 380 | 0.51 | 9.50×10−5 | 2.39×10−2 | 2.167 (1.46 to 3.215） |
| CG | 36 | 0.27 | 312 | 0.42 | 9.87×10−4 | NS | 0.507 (0.337 to 0.764） |
| GG | 5 | 0.04 | 51 | 0.07 | 1.72×10−1 | NS | 0.526 (0.206 to 1.343） |
| C | 222 | 0.83 | 1072 | 0.72 | 2.48×10−4 | 4.17×10−2 | 1.864 (1.33 to 2.611） |
| G | 46 | 0.17 | 414 | 0.28 | 2.48×10−4 | 4.17×10−2 | 0.537 (0.383 to 0.752） |
| JAZF/rs73300638 | |||||||
| CC | 26 | 0.19 | 85 | 0.11 | 1.09×10−2 | NS | 1.861 (1.147 to 3.02） |
| CA | 74 | 0.55 | 325 | 0.44 | 1.45×10−2 | NS | 1.582 (1.093 to 2.291） |
| AA | 34 | 0.25 | 332 | 0.45 | 2.86×10−5 | 7.21×10−3 | 0.42 (0.277 to 0.636） |
| C | 126 | 0.47 | 495 | 0.33 | 1.69×10−5 | 2.84×10−3 | 1.773 (1.363 to 2.306） |
| A | 142 | 0.53 | 989 | 0.67 | 1.69×10−5 | 2.84×10−3 | 0.564 (0.434 to 0.734） |
| IRF5/rs2004640 | |||||||
| GG | 50 | 0.37 | 424 | 0.57 | 2.41×10−5 | 6.07×10−3 | 0.448 (0.307 to 0.654） |
| GT | 71 | 0.53 | 280 | 0.38 | 8.77×10−4 | NS | 1.864 (1.287 to 2.699） |
| TT | 13 | 0.1 | 39 | 0.05 | 4.46×10−2 | NS | 1.939 (1.006 to 3.74） |
| G | 171 | 0.64 | 1128 | 0.76 | 3.17×10−5 | 5.33×10−3 | 0.559 (0.425 to 0.737） |
| T | 97 | 0.36 | 358 | 0.24 | 3.17×10−5 | 5.33×10−3 | 1.787 (1.356 to 2.356） |
| MEFV/rs224217 | |||||||
| AA | 7 | 0.05 | 23 | 0.03 | 2.07×10−1 | NS | 1.737 (0.73 to 4.133） |
| AG | 61 | 0.46 | 226 | 0.3 | 4.92×10−4 | NS | 1.934 (1.329 to 2.815） |
| GG | 65 | 0.49 | 493 | 0.66 | 1.04×10−4 | 2.61×10−2 | 0.483 (0.333 to 0.701） |
| A | 75 | 0.28 | 272 | 0.18 | 2.02×10−4 | 3.39×10−2 | 1.75 (1.299 to 2.356） |
| G | 191 | 0.72 | 1212 | 0.82 | 2.02×10−4 | 3.39×10−2 | 0.572 (0.424 to 0.77） |
| PSM3/rs2348071 | |||||||
| GG | 34 | 0.25 | 119 | 0.16 | 8.61×10−2 | NS | 1.783 (1.153 to 2.756） |
| GA | 76 | 0.57 | 364 | 0.49 | 9.97×10−2 | NS | 1.364 (0.942 to 1.977） |
| AA | 24 | 0.18 | 260 | 0.35 | 1.00×10−4 | 2.53×10−2 | 0.405 (0.254 to 0.646） |
| G | 144 | 0.54 | 602 | 0.41 | 5.60×10−5 | 9.40×10−3 | 1.705 (1.313 to 2.215） |
| A | 124 | 0.46 | 884 | 0.59 | 5.60×10−5 | 9.40×10−3 | 0.586 (0.451 to 0.762） |
| PTPN2/rs7234029 | |||||||
| GG | 20 | 0.15 | 74 | 0.1 | 8.72×10−2 | NS | 1.586 (0.931 to 2.701） |
| GA | 76 | 0.57 | 311 | 0.42 | 1.43×10−2 | NS | 1.82 (1.255 to 2.639） |
| AA | 38 | 0.28 | 358 | 0.48 | 2.19×10−5 | 5.52×10−3 | 0.426 (0.285 to 0.636） |
| G | 116 | 0.43 | 459 | 0.31 | 6.92×10−5 | 1.16×10−2 | 1.708 (1.309 to 2.227） |
| A | 152 | 0.57 | 1027 | 0.69 | 6.92×10−5 | 1.16×10−2 | 0.586 (0.449 to 0.764） |
JIA-U, juvenile idiopathic arthritis associated uveitis; NS, not significant; Pc, Bonferroni corrected p value.