Association of baseline factors with 5-year change rate of TISA500 in dark condition
| Baseline variable | Model 1 coefficient (95% CI) | P value | Model 2 coefficient (95% CI)* | P value |
| Age, year | 0.0226 (−0.0139 to 0.059) | 0.225 | 0.0175 (−0.0127 to 0.0479) | 0.256 |
| Gender (M/F) | −0.1572 (−0.523 to 0.209) | 0.400 | −0.355 (-0.8727 to 0.1626) | 0.179 |
| Weight, kg | 0.0077 (−0.0104 to 0.0260) | 0.404 | 0.0071 (−0.0130 to 0.0273) | 0.488 |
| Height, cm | −0.0085 (−0.0215 to 0.0044) | 0.197 | −0.0343 (−0.0613 to −0.0081) | 0.005 |
| SBP, mm Hg | 0.00021 (−0.0040 to 0.0044) | 0.922 | −0.0026 (−0.0134 to 0.00610) | 0.467 |
| DBP, mm Hg | −0.0038 (−0.0151 to 0.0074) | 0.499 | −0.0016 (−0.0171 to 0.0147) | 0.811 |
| SE, dioptre | −0.0133 (−0.0557 to 0.0291) | 0.538 | −0.0607 (−0.1192 to 0.0158) | 0.151 |
| AL, mm | −0.0077 (−0.0127 to -0.0027) | 0.003 | 0.0218 (−0.0739 to 0.1230) | 0.634 |
| ACD, mm | −0.0124 (−0.3141 to 0.2893) | 0.936 | −0.2211 (−1.234 to 0.7863) | 0.688 |
| LT, mm | −0.0059 (−0.0089 to −0.0028) | 0.011 | 0.0090 (−0.0111 to 0.0296) | 0.120 |
| TISA500, mm2 | −6.2306 (−11.0521 to −1.4090) | <0.001 | −26.838 (−47.262 to −20.203) | 0.008 |
| ARA, mm2 | −2.3040 (−3.9662 to −0.6419) | 0.007 | 6.7115 (−3.6145 to 16.380) | 0.066 |
| IT750, mm | −0.4571 (−1.3943 to 0.4801) | 0.339 | −3.1758 (−4.989 to 0.5221) | 0.003 |
| Iarea, mm2 | 0.1688 (−0.1140 to 0.3451) | 0.067 | 0.7658 (−0.3135 to 1.6066) | 0.094 |
| ACW, mm | 0.7760 (0.2823 to 1.2697) | 0.002 | 0.0221 (−0.5721 to 0.7389) | 0.931 |
| ACA, mm2 | 0.0447 (−0.0312 to 0.1206) | 0.249 | 0.1318 (0.0113 to 0.2838) | 0.023 |
| LV, μm | 0.0002 (−0.0004 to 0.0009) | 0.455 | 0.0001 (−0.00101 to 0.0012) | 0.786 |
| PD, mm | −0.0768 (−0.2502 to 0.0966) | 0.386 | 0.0304 (−0.3108 to 0.3339) | 0.847 |
| ΔARA, mm2 | 1.3023 (−0.0599 to 2.6646) | 0.061 | −2.1270 (−30.0325 to −3.8854) | 0.272 |
| ΔIT750, mm2 | 0.1777 (−0.4321 to 0.7876) | 0.568 | −0.9749 (−1.302 to 11.9384) | 0.266 |
| ΔIarea, mm2 | −0.1074 (−0.2874 to 0.0727) | 0.243 | 0.1311 (−0.66559 to 1.2264) | 0.753 |
| ΔACW, mm | −0.9413 (−1.6071 to −0.2755) | 0.006 | −0.2284 (−1.236 to 1.10341) | 0.643 |
| ΔACA, mm2 | 0.4067 (−0.3564 to 1.169) | 0.296 | 0.4083 (−0.1823 to 0.018) | 0.232 |
| ΔLV,μm | −0.0032 (−0.0060 to 0.0004) | 0.027 | −0.0024 (−0.0060 to −0.0015) | 0.224 |
| ΔPD, mm | 0.0888 (−0.0753 to 0.2731) | 0.266 | 0.0783 (−0.2378 to 0.4040) | 0.662 |
TISA500 change was defined as TISA500 in 2013 minus TISA500 in 2008.
Model 1 is a univariate regression analysis; model 2 is a multiple regression analysis.
Bold indicates statistical significance.
*Adjusted for age, gender, weight, height, SBP, DBP, SE, AL, ACD, LT, TISA500, ARA, IT750, larea, ACW, LV, PD, ΔARA, ΔIT750, ΔIarea, ΔACW, ΔACA, ΔLV, ΔPD.
Δ, light-to-dark changes (dark minus light); ACA, anterior chamber area; ACD, anterior chamber depth; ACW, anterior chamber width; AL, axial length; ARA, angle recess area; DBP, diastolic blood pressure; ΔIT750, iris thickness at 750 µm; Iarea, iris area; LT, lens thickness; LV, lens vault; PD, pupil diameter; SBP, systolic blood pressure; SE, spherical equivalent; TISA500, trabecular iris space area at 500 µm.